Ouyang H, Xing J, Chen J D Z
Transneuronix and Veterans Research & Education Foundation, Oklahoma City, OK, USA.
Neurogastroenterol Motil. 2005 Dec;17(6):846-53. doi: 10.1111/j.1365-2982.2005.00696.x.
It is known that tachygastria is associated with gastric hypomotility and retrograde gastric electrical stimulation (RGES) delays gastric emptying and is proposed for treating obesity. The aim was to investigate the effects and mechanisms of RGES on postprandial antral contraction in dogs.
Seven dogs were implanted with a gastric cannula and three pairs of gastric serosal electrodes. Antral contractions and gastric myoelectrical activity were recorded immediately after a solid meal, with or without RGES, or with GES on the corpus, or with RGES under administration of propranolol. The stimulus was composed of long pulses with a tachygastrial frequency.
(i) GES at the tachygastrial frequency impaired gastric myoelectrical activity and induced tachygastria (anovaP<0.05). (ii) GES at the tachygastrial frequency suppressed antral contractions (anovaP<0.01) and the effect was stronger with retrograde stimulation than forward stimulation (P<0.05). (iii) GES-induced tachygastria was correlated with antral hypomotility (r=-0.60, P=0.01). (iv) Propranolol and phentolamine abolished GES-induced tachygastria and antral hypomotility.
Long-pulse RGES at a tachygastrial frequency suppresses postprandial antral contractions, which is attributed to an induction of tachygastria via the alpha- and beta-adrenergic pathway.
已知快速胃动与胃动力不足有关，逆行胃电刺激（RGES）会延迟胃排空，并被提议用于治疗肥胖症。本研究旨在探讨RGES对犬餐后胃窦收缩的影响及其机制。
七只犬植入胃插管和三对胃浆膜电极。在进食固体食物后，立即记录胃窦收缩和胃肌电活动，记录条件包括施加或不施加RGES、对胃体施加胃电刺激（GES）或在给予普萘洛尔的情况下施加RGES。刺激由具有快速胃动频率的长脉冲组成。
（i）快速胃动频率的GES损害胃肌电活动并诱发快速胃动（方差分析P<0.05）。（ii）快速胃动频率的GES抑制胃窦收缩（方差分析P<0.01），逆行刺激的效果比正向刺激更强（P<0.05）。（iii）GES诱发的快速胃动与胃窦动力不足相关（r=-0.60，P=0.01）。（iv）普萘洛尔和酚妥拉明消除了GES诱发的快速胃动和胃窦动力不足。
快速胃动频率的长脉冲RGES抑制餐后胃窦收缩，这归因于通过α和β肾上腺素能途径诱发快速胃动。
