Cheng Leo K, Nagahawatte Nipuni D, Avci Recep, Du Peng, Liu Zhongming, Paskaranandavadivel Niranchan
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Department of General Surgery, Vanderbilt University Medical Center, Nashville, TN, United States.
Front Neurosci. 2021 Apr 22;15:645472. doi: 10.3389/fnins.2021.645472. eCollection 2021.
Gastric pacing and stimulation strategies were first proposed in the 1960s to treat motility disorders. However, there has been relatively limited clinical translation of these techniques. Experimental investigations have been critical in advancing our understanding of the control mechanisms that innervate gut function. In this review, we will discuss the use of pacing to modulate the rhythmic slow wave conduction patterns generated by interstitial cells of Cajal in the gastric musculature. In addition, the use of gastric high-frequency stimulation methods that target nerves in the stomach to either inhibit or enhance stomach function will be discussed. Pacing and stimulation protocols to modulate gastric activity, effective parameters and limitations in the existing studies are summarized. Mathematical models are useful to understand complex and dynamic systems. A review of existing mathematical models and techniques that aim to help refine pacing and stimulation protocols are provided. Finally, some future directions and challenges that should be investigated are discussed.
胃起搏和刺激策略最早于20世纪60年代被提出用于治疗动力障碍。然而，这些技术在临床应用方面的转化相对有限。实验研究对于推进我们对支配肠道功能的控制机制的理解至关重要。在这篇综述中，我们将讨论使用起搏来调节胃肌层中 Cajal 间质细胞产生的节律性慢波传导模式。此外，还将讨论针对胃神经以抑制或增强胃功能的胃高频刺激方法的使用。总结了现有研究中调节胃活动的起搏和刺激方案、有效参数及局限性。数学模型有助于理解复杂的动态系统。本文提供了对旨在帮助完善起搏和刺激方案的现有数学模型和技术的综述。最后，讨论了一些未来应研究的方向和挑战。
