Arafa M M, ElBardisi H T, AlSaid S S, Majzoub A, AlMalki A H, ElRobi I, AlAnsari A A
Urology Department, Hamad Medical Corporation, Doha, Qatar.
Andrology Department, Cairo University Medical School, Cairo, Egypt.
Andrologia. 2015 Nov;47(9):1062-7. doi: 10.1111/and.12378. Epub 2014 Nov 18.
The aim of the study was to evaluate the sperm retrieval rate by microsurgical testicular sperm extraction (TESE) in familial idiopathic nonobstructive azoospermia (NOA). One hundred and nineteen patients with idiopathic NOA who underwent microsurgical TESE over the past 5 years were included. Patients were then divided into two groups; Group 'A' with familial idiopathic NOA (11 families with two brothers in each family, 22 patients) and Group 'B' with nonfamilial idiopathic NOA (97 patients). Clinical data as well as data of microsurgical TESE were recorded. In Group 'A', the sperm retrieval rate was 9.1% (2/22 patients) compared to 45.4% in Group 'B' (44/97 patients) (P ≤ 0.05). The two patients in Group 'A' with successful sperm retrieval belonged to one family. The histopathological diagnosis was the same in the brothers in each family. It can be concluded that the testicular sperm retrieval rate in familial idiopathic NOA is significantly lower than in nonfamilial idiopathic NOA.
本研究的目的是评估显微外科睾丸精子提取术（TESE）在家族性特发性非梗阻性无精子症（NOA）中的精子获取率。纳入了过去5年中接受显微外科TESE的119例特发性NOA患者。然后将患者分为两组；A组为家族性特发性NOA（11个家庭，每个家庭有两个兄弟，共22例患者），B组为非家族性特发性NOA（97例患者）。记录临床数据以及显微外科TESE的数据。A组的精子获取率为9.1%（2/22例患者），而B组为45.4%（44/97例患者）（P≤0.05）。A组中成功获取精子的两名患者来自同一个家庭。每个家庭中兄弟的组织病理学诊断相同。可以得出结论，家族性特发性NOA的睾丸精子获取率明显低于非家族性特发性NOA。
