Feyereisen René
Institut Sophia Agrobiotech, Sophia Antipolis, France.
Pest Manag Sci. 2015 Jun;71(6):793-800. doi: 10.1002/ps.3895. Epub 2014 Nov 17.
P450 enzymes are encoded by a large number of genes in insects, often over a hundred. They play important roles in insecticide metabolism and resistance, and growing numbers of P450 enzymes are now known to catalyse important physiological reactions, such as hormone metabolism or cuticular hydrocarbon synthesis. Ways to inhibit P450 enzymes specifically or less specifically are well understood, as P450 inhibitors are found as drugs, as fungicides, as plant growth regulators and as insecticide synergists. Yet there are no P450 inhibitors as insecticides on the market. As new modes of action are constantly needed to support insecticide resistance management, P450 inhibitors should be considered because of their high potential for insect selectivity, their well-known mechanisms of action and the increasing ease of rational design and testing.
细胞色素P450酶由昆虫体内大量基因编码，通常有上百个。它们在杀虫剂代谢和抗性方面发挥着重要作用，如今已知越来越多的细胞色素P450酶能催化重要的生理反应，如激素代谢或表皮碳氢化合物合成。特异性或非特异性抑制细胞色素P450酶的方法已为人熟知，因为细胞色素P450抑制剂可作为药物、杀菌剂、植物生长调节剂和杀虫剂增效剂。然而，市场上没有作为杀虫剂的细胞色素P450抑制剂。由于持续需要新的作用模式来支持杀虫剂抗性管理，细胞色素P450抑制剂因其具有高度的昆虫选择性潜力、广为人知的作用机制以及越来越便于合理设计和测试，应予以考虑。
