从人扁桃体获得的细胞的自发淋巴母细胞转化。
Spontaneous lymphoblastoid transformation of cells obtained from human tonsils.
作者信息
Takimoto T, Tanaka S, Masuda K, Umeda R
机构信息
Department of Otolaryngology, School of Medicine, Kanazawa University, Japan.
出版信息
ORL J Otorhinolaryngol Relat Spec. 1989;51(2):77-82. doi: 10.1159/000276037.
Spontaneous lymphoblastoid transformation of cells obtained from 25 human tonsils were investigated. Three Epstein-Barr virus (EBV) genome-positive lymphoblastoid cell lines were spontaneously established in tissue cultures in vitro from human tonsils. In addition, the frequency of spontaneous lymphoblastoid transformation was increased by the treatment of tumor promoter, 12-0-tetradecanoylphorbol-13-acetate and 18 lymphoblastoid cell lines were established. The data suggest that the human tonsil is a reservoir for EBV.
对从25个人类扁桃体获取的细胞进行了自发淋巴母细胞转化的研究。在体外组织培养中，从人类扁桃体自发建立了3株爱泼斯坦-巴尔病毒（EBV）基因组阳性的淋巴母细胞系。此外，通过肿瘤启动子12-0-十四酰佛波醇-13-乙酸酯处理可增加自发淋巴母细胞转化的频率，并建立了18株淋巴母细胞系。数据表明人类扁桃体是EBV的储存库。
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