Hinson Ashley, Newbern Dorothee, Linardic Corinne M
Department of Pediatrics, Duke University Medical Center, Box 102382, Durham, NC 27710, USA.
Department of Pediatrics, Phoenix Children's Hospital, 1919 E. Thomas Road, Phoenix, AZ 85016, USA.
Case Rep Pediatr. 2014;2014:635740. doi: 10.1155/2014/635740. Epub 2014 Oct 27.
Asparaginase is a chemotherapeutic agent used to induce disease remission in children with acute lymphoblastic leukemia (ALL). We describe the cases of two females with ALL who developed pseudohyponatremia as a presentation of hypertriglyceridemia following asparaginase treatment. Nine similar published cases of asparaginase-induced hypertriglyceridemia and its complications are also discussed. Possible mechanisms of action include inhibition of lipoprotein lipase, decreased hepatic synthesis of lipoprotein, and increased synthesis of VLDL. Effects of asparaginase-induced hypertriglyceridemia range from asymptomatic to transaminasemia, pancreatitis, and life-threatening thrombosis or hyperviscosity syndrome. All cases of hypertriglyceridemia described resolved following cessation of asparaginase treatment ± further treatments.
天冬酰胺酶是一种用于诱导急性淋巴细胞白血病（ALL）患儿疾病缓解的化疗药物。我们描述了两名患ALL的女性患者，她们在接受天冬酰胺酶治疗后出现了假性低钠血症，表现为高甘油三酯血症。还讨论了9例已发表的类似天冬酰胺酶诱导的高甘油三酯血症及其并发症的病例。可能的作用机制包括抑制脂蛋白脂肪酶、减少肝脏脂蛋白合成以及增加极低密度脂蛋白（VLDL）的合成。天冬酰胺酶诱导的高甘油三酯血症的影响范围从无症状到转氨酶升高、胰腺炎以及危及生命的血栓形成或高黏滞综合征。所描述的所有高甘油三酯血症病例在停用天冬酰胺酶治疗±进一步治疗后均得到缓解。
