Keung Y K, Rizk R, Wu X Y, Cobos E
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
South Med J. 1999 Sep;92(9):912-4. doi: 10.1097/00007611-199909000-00013.
We describe two cases of drug-induced hypertriglyceridemia, one associated with interferon alfa-2b and the other with asparaginase, each of which is mediated through a different mechanism. Hypertriglyceridemia caused by these medications is not listed as an adverse reaction in the Physicians' Desk Reference, one of the most popular pharmacologic reference sources used in the United States. We emphasize the importance of early recognition of this metabolic effect and the potential life-threatening complication, acute pancreatitis.
我们描述了两例药物性高甘油三酯血症，一例与干扰素α-2b有关，另一例与天冬酰胺酶有关，每例均通过不同机制介导。这些药物引起的高甘油三酯血症在美国最常用的药理学参考资料之一《医师案头参考》中未被列为不良反应。我们强调早期识别这种代谢效应以及潜在的危及生命的并发症——急性胰腺炎的重要性。
