Cascioferro Stella, Cusimano Maria Grazia, Schillaci Domenico
Department of Biological, Chemical & Pharmaceutical Science & Technology (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, Palermo, Italy.
Future Microbiol. 2014;9(10):1209-20. doi: 10.2217/fmb.14.56.
A fundamental step of Gram-positive pathogenesis is the bacterial adhesion to the host tissue involving interaction between bacterial surface molecules and host ligands. This review is focused on antivirulence compounds that target Gram-positive adhesins and on their potential development as therapeutic agents alternative or complementary to conventional antibiotics in the contrast of pathogens. In particular, compounds that target the sortase A, wall theicoic acid inhibitors, carbohydrates able to bind bacterial proteins and proteins capable of influencing the bacterial adhesion, were described. We further discuss the advantages and disadvantages of this strategy in the development of novel antimicrobials and the future perspective of this research field still at its first steps.
革兰氏阳性菌致病的一个基本步骤是细菌与宿主组织的黏附，这涉及细菌表面分子与宿主配体之间的相互作用。本综述聚焦于靶向革兰氏阳性菌黏附素的抗毒力化合物，以及它们作为治疗剂替代或补充传统抗生素用于对抗病原体的潜在发展前景。特别描述了靶向分选酶A的化合物、细胞壁磷壁酸抑制剂、能够结合细菌蛋白的碳水化合物以及能够影响细菌黏附的蛋白质。我们进一步讨论了这一策略在新型抗菌药物开发中的优缺点，以及这个仍处于起步阶段的研究领域的未来前景。
