Eisenstädter A, Seiser A, Brainin M
Neurologische Abteilung, NO Landeskrankenhaus Klosterneuburg.
Wien Klin Wochenschr. 1989 Mar 3;101(5):166-8.
In a series of 16 patients on long-term lithium therapy pathological changes were found in peripheral nerve conduction. Such changes correlated with the duration of lithium therapy (mean: 8.3 years, range: 3-15 years; p less than 0.05). No patient showed clinical signs of polyneuropathy or any other disease known to be frequently associated with peripheral nerve lesions. Compared with an age-matched normal control group (n = 27) the nerve conduction velocity of the sural nerve was reduced (p less than 0.05), for which a chronic neurotoxic effect is considered to be the most probable mechanism.
在一组接受长期锂盐治疗的16例患者中，发现外周神经传导存在病理变化。这些变化与锂盐治疗的持续时间相关（平均：8.3年，范围：3 - 15年；p<0.05）。没有患者表现出多发性神经病的临床体征或任何其他已知常与外周神经病变相关的疾病。与年龄匹配的正常对照组（n = 27）相比，腓肠神经的神经传导速度降低（p<0.05），最可能的机制被认为是慢性神经毒性作用。
