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个体生育力评估与促生育咨询;是否应向育龄男女提供此项服务?

Individual fertility assessment and pro-fertility counselling; should this be offered to women and men of reproductive age?

作者信息

Hvidman Helene W, Petersen Kathrine Birch, Larsen Elisabeth C, Macklon Kirsten Tryde, Pinborg Anja, Nyboe Andersen Anders

机构信息

The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

出版信息

Hum Reprod. 2015 Jan;30(1):9-15. doi: 10.1093/humrep/deu305. Epub 2014 Nov 17.

Abstract

During the 1970s new contraceptive options developed and legal abortions became accessible. Family planning clinics targeting young women and men provided advice and assistance on contraception. Today, delayed childbearing, low total fertility rates and increasing use of social oocyte freezing create a need for pro-fertility initiatives. Three years ago we established a new separate unit: The Fertility Assessment and Counselling (FAC) clinic. The FAC clinic offers free individual counselling based on a clinical assessment including measurement of serum anti-Müllerian hormone and ovarian and pelvic sonography in women, sperm analysis in men, and a review of reproductive risk factors in both sexes. The FAC clinic includes a research programme with the goal to improve prediction and protection of fertility. Our first proposition is that clinics for individual assessment and counselling need to be established, as there is a strong unmet demand among women and men to obtain: (i) knowledge of fertility status, (ii) knowledge of reproductive lifespan (women) and (iii) pro-fertility advice. Addressing these issues is often more challenging than treating infertile patients. Therefore, we propose that fertility assessment and counselling should be developed by specialists in reproductive medicine. There are two main areas of concern: As our current knowledge on reproductive risk factors is primarily based on data from infertile patients, the first concern is how precisely we are able to forecast future reproductive problems. Predictive parameters from infertile couples, such as duration of infertility, are not applicable, diagnostic factors like tubal patency are unavailable and other parameters may be unsuitable when applied to the general population. Therefore, strict validation of reproductive forecasting in women and men from the general population is crucial. The second main concern is that we may turn clients into patients. Screening including reproductive forecasting may induce unnecessary anxiety through false positive predictions and may even result in overtreatment in contrast to the intended preventive concept. False negative findings may create false reassurance and result in postponement of conceptions.

摘要

20世纪70年代,新的避孕方法不断涌现,合法堕胎也变得可行。面向年轻男女的计划生育诊所提供避孕方面的建议和帮助。如今,生育推迟、总和生育率降低以及社会卵子冷冻的使用增加,使得生育促进举措成为必要。三年前,我们设立了一个新的独立科室:生育力评估与咨询(FAC)诊所。FAC诊所基于临床评估提供免费的个人咨询服务,临床评估包括测量女性血清抗苗勒管激素、卵巢和盆腔超声检查、男性精液分析以及对男女双方生殖风险因素的评估。FAC诊所还包括一个研究项目,目标是改进生育力的预测和保护。我们的首要主张是,需要设立个体评估和咨询诊所,因为男女对获取以下方面存在强烈的未满足需求:(i)生育状况知识;(ii)生殖寿命知识(女性);(iii)生育促进建议。解决这些问题往往比治疗不孕患者更具挑战性。因此,我们建议生育力评估和咨询应由生殖医学专家开展。有两个主要关注点:由于我们目前对生殖风险因素的了解主要基于不孕患者的数据,第一个关注点是我们能够多精确地预测未来的生殖问题。不孕夫妇的预测参数,如不孕持续时间,并不适用,像输卵管通畅性这样的诊断因素不可用,而其他参数应用于普通人群时可能不合适。因此,对普通人群中男女的生殖预测进行严格验证至关重要。第二个主要关注点是,我们可能会将客户变成患者。包括生殖预测在内的筛查可能会通过假阳性预测引发不必要的焦虑,甚至可能导致与预期的预防理念相反的过度治疗。假阴性结果可能会产生错误的安心感,并导致受孕推迟。

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