Khan Amjad, Shaw Lindsay, Bernatoniene Jolanta
Paediatric Dermatology department, Great Ormond Street Hospital, London, UK.
Paediatric Infectious Disease & Immunology department, Bristol Royal Hospital for Children, Bristol, UK.
Arch Dis Child Educ Pract Ed. 2015 Apr;100(2):64-8. doi: 10.1136/archdischild-2013-304460. Epub 2014 Nov 18.
Eczema herpeticum (EH) occurs when there is secondary skin infection with herpes simplex virus in an atopic patient. The patient may not have unusually severe or active eczema. It is thought that the abnormal skin barrier function predisposes to infection, which can spread rapidly. Viraemia and secondary septicaemia can occur, and the condition can be life-threatening. The first episode of herpes infection is usually the worst and requires systemic treatment. Early recognition is vital. The presentation may be difficult to distinguish from secondary bacterial infection, which is common in eczema. A useful clinical clue is the presence of many very similar shaped and sized eroded lesions. Intact blisters may not be seen due to scratching. A rapid deterioration in eczema in a child who is systemically unwell should prompt consideration of EH.
疱疹样湿疹(EH)发生于特应性患者继发单纯疱疹病毒皮肤感染时。患者的湿疹可能并不异常严重或处于活动期。据认为,异常的皮肤屏障功能易引发感染,且感染可迅速扩散。可发生病毒血症和继发性败血症,病情可能危及生命。疱疹感染的首发通常最为严重,需要进行全身治疗。早期识别至关重要。其表现可能难以与湿疹中常见的继发性细菌感染相区分。一个有用的临床线索是存在许多形状和大小非常相似的糜烂性病变。由于搔抓,可能看不到完整的水疱。全身不适的儿童湿疹迅速恶化应促使考虑疱疹样湿疹。