Daurio Dominick, Nagapudi Karthik, Li Lan, Quan Peter, Nunez Fernando-Alvarez
Amgen Inc., Small Molecule Process & Product Development, Thousand Oaks, California, USA.
Faraday Discuss. 2014;170:235-49. doi: 10.1039/c3fd00153a.
The application of twin screw extrusion (TSE) in the scale-up of cocrystal production was investigated by using AMG 517-sorbic acid as a model system. Extrusion parameters that influenced conversion to the cocrystal such as temperature, feed rate and screw speed were investigated. Extent of conversion to the cocrystal was found to have a strong dependence on temperature and a moderate dependence on feed rate and screw speed. Cocrystals made by the TSE process were found to have superior mechanical properties than solution grown cocrystals. Additionally, moving to a TSE process eliminated the need for solvent.
以AMG 517-山梨酸为模型体系，研究了双螺杆挤出（TSE）在共晶生产放大中的应用。研究了影响向共晶转化的挤出参数，如温度、进料速率和螺杆转速。发现向共晶的转化程度强烈依赖于温度，对进料速率和螺杆转速有中等程度的依赖。通过TSE工艺制备的共晶具有比溶液生长的共晶更好的机械性能。此外，采用TSE工艺无需使用溶剂。
