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2006年至2012年北京通州区出生缺陷患病率

[Prevalence of birth defects in the Tongzhou District of Beijing between 2006 and 2012].

作者信息

Yu Jing-Ru, Jin Lei, Xiao Li-Hua, Jin Lei

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2014 Nov;16(11):1133-7.

Abstract

OBJECTIVE

To study the dynamic prevalence and epidemiological characteristics of birth defects distribution in the Tongzhou District of Beijing between 2006 and 2012.

METHODS

Data collected from the birth defects surveillance system in the Tongzhou District of Beijing between 2006 and 2012 were used. The prevalence and trends of birth defects were analyzed, also the proportion of birth defects in prenatal diagnosis was calculated.

RESULTS

Between 2006 and 2012, 1,165 cases of birth defects were identified among 92,340 births, with a prevalence of 12.62‰. The prevalence of birth defects showed an increased trend during the seven years (χ2=6.77, P<0.01). The prevalence in the flowing population (13.27‰) was higher than that in the permanent residents (11.55‰), and the former showed an upward trend during the seven years (χ2=25.02, P<0.01). The top five birth defects were congenital heart defects, polydactyly, cleft lip and/or palate, neural tube defects, and external ear malformation in turn. The prevalence of congenital heart defects and the unspecified congenital malformation increased while that of neural tube defects decreased. There was also an upward trend of the prenatal diagnosis for congenital heart defects (χ2=14.80, P<0.01).

CONCLUSIONS

The prevalence of birth defects increased in the Tongzhou District of Beijing from 2006 to 2012, and it was mainly caused by the increased prevalence of birth defects in the flowing population, the increased number of unspecified birth defects and the improvement of diagnosis technology for congenital heart defects.

摘要

目的

研究2006年至2012年北京市通州区出生缺陷的动态患病率及分布的流行病学特征。

方法

采用2006年至2012年北京市通州区出生缺陷监测系统收集的数据。分析出生缺陷的患病率及趋势,并计算产前诊断中出生缺陷的比例。

结果

2006年至2012年,92340例出生中确诊1165例出生缺陷,患病率为12.62‰。七年间出生缺陷患病率呈上升趋势(χ2=6.77,P<0.01)。流动人口患病率(13.27‰)高于常住人口(11.55‰),且七年间前者呈上升趋势(χ2=25.02,P<0.01)。前五位出生缺陷依次为先天性心脏病、多指(趾)畸形、唇腭裂、神经管缺陷和外耳畸形。先天性心脏病和未特定的先天性畸形患病率上升,而神经管缺陷患病率下降。先天性心脏病产前诊断率也呈上升趋势(χ2=14.80,P<0.01)。

结论

2006年至2012年北京市通州区出生缺陷患病率上升,主要原因是流动人口出生缺陷患病率增加、未特定出生缺陷数量增加以及先天性心脏病诊断技术提高。

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