Liu Jianchao, Lu Guanghua, Zhang Zhenghua, Bao Yijun, Liu Fuli, Wu Donghai, Wang Yonghua
Key Laboratory for Integrated Regulation and Resources Development on Shallow Lakes, China Ministry of Education, College of Environment, Hohai University, 1 Xikang Road, 210098 Nanjing, China.
Environ Sci Process Impacts. 2015 Jan;17(1):54-61. doi: 10.1039/c4em00472h. Epub 2014 Nov 12.
Pharmaceutically active compounds (PhACs) have been universally detected in rivers, lakes and coastal waters that are affected by effluents from sewage treatment plants (STPs). In this study, the biological effects and bioaccumulation of PhACs were assessed in crucian carp (Carassius auratus) caged in an effluent-receiving river for 21 days. Compared with control fish in the laboratory and at a reference site, a significant reduction in hepatosomatic index (HSI) and increase in the biotransformation enzymes ethoxyresorufin O-deethylase (EROD) and glutathione S-transferase (GST) activities were observed in the fish that was caged downstream from the STP outfall. In general, the total concentrations of PhACs detected in fish tissues were in the order as follows: liver > brain > gill > muscle > bile. The bioaccumulation factors (BAFs) for PhACs were between 195 and 2782 in the major storage tissue liver. The corresponding results for both risk quotient (RQ) and enhanced integrated biomarker response (EIBR) based on laboratory and field studies, respectively, indicated that environmental risk for adverse effects to aquatic organisms were clearly higher at the downstream of the STP outfall than at the upstream.
在受污水处理厂（STP）废水影响的河流、湖泊和沿海水域中，普遍检测到了具有药物活性的化合物（PhACs）。在本研究中，对置于受纳废水河流中的鲫鱼（Carassius auratus）进行了21天的PhACs生物效应和生物累积评估。与实验室和参考点的对照鱼相比，在STP排放口下游网箱养殖的鱼中，观察到肝体指数（HSI）显著降低，生物转化酶乙氧基异吩唑酮 - O - 脱乙基酶（EROD）和谷胱甘肽 - S - 转移酶（GST）活性增加。总体而言，在鱼组织中检测到的PhACs总浓度顺序如下：肝脏＞脑＞鳃＞肌肉＞胆汁。在主要储存组织肝脏中，PhACs的生物累积因子（BAFs）在195至2782之间。分别基于实验室和现场研究的风险商（RQ）和增强综合生物标志物反应（EIBR）的相应结果表明，STP排放口下游对水生生物产生不利影响的环境风险明显高于上游。
