Ostrow R S, Shaver M K, Turnquist S, Viksnins A, Bender M, Vance C, Kaye V, Faras A J
Department of Microbiology, School of Medicine, University of Minnesota, Minneapolis 55455.
Arch Dermatol. 1989 May;125(5):666-9.
A middle-aged man with a 20-year history of a warty lesion on his finger was diagnosed histologically as having an invasive carcinoma at that location. Molecular analysis of the lesion showed that human papillomavirus (HPV) DNA was present in this tumor. Under stringent hybridization conditions, only HPV-16 DNA, which is commonly associated with genital neoplasia or cutaneous bowenoid lesions, was detected. Two-dimensional gel electrophoresis revealed that various sections of the tumor contained mostly episomal viral DNA; but in one case, low levels of integrated HPV-16 DNA were detected as well.
一名手指有20年疣状病变史的中年男性经组织学诊断为该部位浸润性癌。对该病变进行分子分析显示，该肿瘤中存在人乳头瘤病毒（HPV）DNA。在严格的杂交条件下，仅检测到通常与生殖器肿瘤或皮肤鲍温样病变相关的HPV-16 DNA。二维凝胶电泳显示，肿瘤的各个部分大多含有游离型病毒DNA；但在一个病例中，也检测到了低水平的整合型HPV-16 DNA。
