Ahmed Zahra, Kawamura Tatsuyoshi, Shimada Shinji, Piguet Vincent
Department of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK.
Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
J Invest Dermatol. 2015 May;135(5):1225-1233. doi: 10.1038/jid.2014.490. Epub 2014 Nov 19.
Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.
树突状细胞（DCs）及其亚群在HIV-1传播和感染的早期阶段具有多方面的作用。对DC的研究带来了显著的发现，包括限制因子的鉴定、促进病毒传播的细胞结构（如感染性突触）或C型凝集素之间的相互作用，朗格汉斯细胞（LCs）上的朗格蛋白以及其他DC亚群上的树突状细胞特异性细胞间黏附分子3抓取非整合素，它们分别限制或促进HIV向CD4(+) T细胞的传播。LCs/DCs还会接触到HIV-1和其他性传播感染（单纯疱疹病毒2型、细菌、真菌），这些会重新编程HIV-1与这些细胞的相互作用。本综述将总结DCs在HIV-1感染过程中的作用进展，并讨论它们在制定针对HIV-1和其他性传播感染的预防策略中可能发挥的作用。
