基于单个银纳米立方体的折射率相关实时等离子体纳米探针用于肺癌相关微小RNA的超灵敏检测
Refractive index dependent real-time plasmonic nanoprobes on a single silver nanocube for ultrasensitive detection of the lung cancer-associated miRNAs.
作者信息
Zhang Lei, Zhang Ying, Hu Yanling, Fan Quli, Yang Wenjing, Li Anran, Li Shuzhou, Huang Wei, Wang Lianhui
机构信息
Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
出版信息
Chem Commun (Camb). 2015;51(2):294-7. doi: 10.1039/c4cc06663d. Epub 2014 Nov 12.
We developed a novel method for the real-time monitoring of the delicate change in refractive index (RI) when DNA or RNA hybridize near a DNA-capped silver nanocube (AgNC) surface. This method offers an alternative platform in the quantitative analysis of the trace lung cancer-associated miRNAs in label-free detection.
我们开发了一种新方法，用于实时监测当DNA或RNA在DNA包覆的银纳米立方体（AgNC）表面附近杂交时折射率（RI）的细微变化。该方法为无标记检测中痕量肺癌相关微小RNA的定量分析提供了一个替代平台。
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