Rüdlinger R, Bunney M H, Grob R, Hunter J A
Department of Dermatology, University Hospital, Zürich, Switzerland.
Br J Dermatol. 1989 Mar;120(3):375-81. doi: 10.1111/j.1365-2133.1989.tb04163.x.
Fish handlers frequently suffer from hand warts. The clinical form and HPV type in these lesions were studied. Eleven individuals (10 fishmongers and one fisherman) with multiple hand warts were examined clinically and samples from their warts examined by Southern blot and reverse blot analysis. Clinically, with one exception, the warts were of the common type. HPV DNA was detected in all but one individual. HPV4 was found in one sample, HPV1 related virus in three, a virus hybridizing with both HPV27 and HPV2 in five (four individuals) and HPV7 in seven (six individuals). More than one type was detected in four individuals. HPV7 infection was related to the greater length of time spent in handling fish. These findings indicate that HPV7 is not, as was previously thought, found exclusively in those handling butcher meat and suggest that environmental conditions may be a factor in the clinical manifestation of HPV7 infection. The exact nature of a virus designated HPV2/27 and the significance of its presence in these fish handlers remains uncertain.
从事鱼类处理工作的人经常患手部疣。对这些病变的临床形式和人乳头瘤病毒（HPV）类型进行了研究。对11名患有多发性手部疣的个体（10名鱼贩和1名渔民）进行了临床检查，并通过Southern印迹法和反向印迹分析法对其疣的样本进行了检测。临床上，除1例例外，疣均为常见类型。除1名个体外，在所有个体中均检测到HPV DNA。在1个样本中发现了HPV4，3个样本中发现了与HPV1相关的病毒，5组样本（4名个体）中发现了一种与HPV27和HPV2均杂交的病毒，7组样本（6名个体）中发现了HPV7。在4名个体中检测到不止一种类型。HPV7感染与处理鱼类的时间较长有关。这些发现表明，HPV7并非如先前认为的那样仅在处理屠宰肉类的人群中出现，提示环境条件可能是HPV7感染临床表现的一个因素。一种被命名为HPV2/27的病毒的确切性质及其在这些鱼类处理者中存在的意义仍不确定。
