Greenspan D, de Villiers E M, Greenspan J S, de Souza Y G, zur Hausen H
Department of Stomatology, University of California, San Francisco 94143-0512.
J Oral Pathol. 1988 Nov;17(9-10):482-8. doi: 10.1111/j.1600-0714.1988.tb01321.x.
Human papillomaviruses (HPV) are associated with certain oral soft tissue lesions, such as papillomas, warts, condylomata, and focal epithelial hyperplasia (FEH). HPV types 2, 6, 11, 16, and 18 have been identified in some of these oral lesions, while HPV 13 and 32 are associated with FEH. Little is known about the HPV types in oral warts of persons infected with human immunodeficiency virus (HIV). In this study, oral warts in 17 HIV-seropositive individuals were biopsied. Southern blot analyses were performed and the HPV types found were HPV 7 (7/17), 13 (1/17), 32 (1/17), and 18 (1/17). The presence of HPV type 7 is unusual in that it normally is found only in butcher's warts. There was no correlation between HPV type, histopathology, and clinical appearance of the lesions examined, except that the flat (FEH type) warts contained HPV types 13, 18 and 32 (1 of each). HIV infection appears to predispose individuals to oral infection with unusual HPV types.
人乳头瘤病毒（HPV）与某些口腔软组织病变有关，如乳头状瘤、疣、湿疣和局灶性上皮增生（FEH）。在其中一些口腔病变中已鉴定出HPV 2型、6型、11型、16型和18型，而HPV 13型和32型与FEH有关。对于感染人类免疫缺陷病毒（HIV）的人的口腔疣中的HPV类型了解甚少。在本研究中，对17名HIV血清阳性个体的口腔疣进行了活检。进行了Southern印迹分析，发现的HPV类型为HPV 7（7/17）、13（1/17）、32（1/17）和18（1/17）。HPV 7型的存在并不常见，因为它通常仅在屠夫疣中发现。在所检查病变的HPV类型、组织病理学和临床表现之间没有相关性，只是扁平（FEH型）疣含有HPV 13型、18型和32型（各1例）。HIV感染似乎使个体易患不寻常HPV类型的口腔感染。
