Roehl Bryan C, Breese McCoy Sarah J, Payton Mark E, Witter LouAnn C
Women's Health Care, Ada, Oklahoma, USA.
Department of Physiology, Oklahoma State University Center for Health Sciences and College of Osteopathic Medicine and Surgery, Tulsa, Oklahoma, USA.
JSLS. 2014 Oct-Dec;18(4). doi: 10.4293/JSLS.2014.00204.
We investigated whether there was a statistically significant difference in patient need for postoperative analgesia based on adjusted body weight between heavier and lighter women who underwent laparoscopic tubal ligation with bupivacaine injection at the skin incision.
We examined 49 records of women who underwent laparoscopic tubal ligation at Oklahoma State University Medical Center between 2000 and 2005 and received an injection of bupivacaine at the surgical site during the procedure. Postsurgical morphine was measured as doses per kilogram of body weight against total body weight and as total milligrams per kilogram of body weight against total body weight. A regression was performed for each measurement.
Heavier women required significantly fewer total milligrams of morphine per kilogram of body weight and fewer total doses of morphine per kilogram of body weight than lighter women (2-tailed P = .0035 and P = .0018, respectively).
Our data may suggest that lipophilic bupivacaine injected at a surgical site is held in place better and works for a longer period when more fat is present.
我们调查了在皮肤切口处注射布比卡因进行腹腔镜输卵管结扎术的体重较重和较轻的女性患者，基于调整体重后的术后镇痛需求是否存在统计学上的显著差异。
我们查阅了2000年至2005年期间在俄克拉荷马州立大学医学中心接受腹腔镜输卵管结扎术且术中在手术部位注射布比卡因的49名女性的记录。术后吗啡用量以每千克体重的剂量相对于总体重以及每千克体重的总毫克数相对于总体重进行测量。对每次测量进行回归分析。
体重较重的女性每千克体重所需的吗啡总毫克数和每千克体重的吗啡总剂量均显著少于体重较轻的女性（双侧P值分别为0.0035和0.0018）。
我们的数据可能表明，在手术部位注射的亲脂性布比卡因，在脂肪较多时能更好地固定在位并发挥更长时间的作用。
