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牙龈增生作为钙通道阻滞剂给药的继发效应。一例报告。

Gingival overgrowth as secondary effect of calcium channel blockers administration. A case report.

作者信息

Mironiuc-Cureu M, Dumitriu A S, Gheorghiu I M, Stoian I M

机构信息

Department of Periodontology, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest.

Department of Operative Dentistry, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest.

出版信息

J Med Life. 2014 Jun 15;7(2):241-5. Epub 2014 Jun 25.

PMID:25408733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4197502/
Abstract

Gingival overgrowth is, among other things, a side effect of the administration of dihydropyridine antihypertensives, generally associated with irritant factors of marginal periodontium. This case refers to a patient, female, who developed a large gingival enlargement that has a combined etiology: the systemic medication with lercanidipina and the presence of dental bridges, which are incorrectly adjusted to the dental cervix. The treatment for this case, involved a complex local treatment (antimicrobial, surgical, endodontic and prosthetic) and the collaboration with a specialist cardiologist. Maintaining the normal gingival parameters in time depends on the possibility of changing the antihypertensive medication, the accuracy of the new dental bridges and the periodic monitoring of the patient.

摘要

牙龈增生是二氢吡啶类抗高血压药物给药的副作用之一，通常与边缘性牙周炎的刺激因素有关。本病例涉及一名女性患者，她出现了大面积牙龈肿大，病因是多方面的：服用乐卡地平进行全身药物治疗以及存在未正确贴合牙颈部的牙桥。该病例的治疗包括复杂的局部治疗（抗菌、手术、牙髓和修复治疗）以及与心脏病专家的合作。及时维持正常的牙龈参数取决于更换抗高血压药物的可能性、新牙桥的准确性以及对患者的定期监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/cefe6a4215c8/JMedLife-07-241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/38c659d64840/JMedLife-07-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/0f276e5f6745/JMedLife-07-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/55add2b536ba/JMedLife-07-241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/06fb8f07ec2d/JMedLife-07-241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/4d6ffb1126dd/JMedLife-07-241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/cefe6a4215c8/JMedLife-07-241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/38c659d64840/JMedLife-07-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/0f276e5f6745/JMedLife-07-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/55add2b536ba/JMedLife-07-241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/06fb8f07ec2d/JMedLife-07-241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/4d6ffb1126dd/JMedLife-07-241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c007/4197502/cefe6a4215c8/JMedLife-07-241-g006.jpg

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本文引用的文献

1
Effect of nifedipine on the expression of keratinocyte growth factor and its receptor in cocultured/monocultured fibroblasts and keratinocytes.硝苯地平对共培养/单纯培养成纤维细胞和角质细胞中角质细胞生长因子及其受体表达的影响。
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Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): histochemical and MMP-1 and -2 and collagen I gene expression analyses.
环孢素、苯妥英和硝苯地平对簇绒卷尾猴（僧帽猴）牙龈胶原合成与降解的影响：组织化学及基质金属蛋白酶-1、-2与I型胶原基因表达分析
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Nifedipine induces gingival overgrowth in rats through a reduction in collagen phagocytosis by gingival fibroblasts.硝苯地平通过减少牙龈成纤维细胞对胶原蛋白的吞噬作用，诱导大鼠牙龈增生。
J Periodontol. 2001 Aug;72(8):1078-83. doi: 10.1902/jop.2001.72.8.1078.