Khocht A, Schneider L C
Department of Periodontics, University of Medicine and Dentistry of New Jersey, Newark, USA.
J Periodontol. 1997 Nov;68(11):1140-6. doi: 10.1902/jop.1997.68.11.1140.
Heart transplant patients take several medications that could affect their periodontal health. Gingival overgrowth associated with cyclosporin (immunosuppressant agent) and nifedipine (calcium channel blocker) is well documented. Candidal infections often develop because of immune suppression. This report describes the clinical and histopathological changes in the gingival tissues of a heart transplant patient and their management. The gingival tissues exhibited pronounced enlargement. The gingivae were lobulated, and the surface of the lobulations was pebbly and granular. Biopsies showed lobules of fibrous connective tissue covered by stratified squamous epithelium. The outer surfaces were dotted with numerous smaller papillations. Candidal hyphae were present in the superficial layers of the epithelium. The extensive papillary lesions appear to be related to candidiasis and constitute a condition which is best designated as papillary stomatitis. Hyperplastic gingival tissues were excised, and the patient was placed on periodic maintenance. One-year postoperative follow-up showed minor gingival growth.
心脏移植患者服用的多种药物可能会影响其牙周健康。与环孢素（免疫抑制剂）和硝苯地平（钙通道阻滞剂）相关的牙龈增生已有充分记录。由于免疫抑制，念珠菌感染经常发生。本报告描述了一名心脏移植患者牙龈组织的临床和组织病理学变化及其处理方法。牙龈组织呈现出明显的肿大。牙龈呈分叶状，叶表面呈卵石状且颗粒状。活检显示纤维结缔组织小叶被复层鳞状上皮覆盖。外表面布满了许多较小的乳头状突起。上皮表层存在念珠菌菌丝。广泛的乳头状病变似乎与念珠菌病有关，构成一种最宜称为乳头状口炎的病症。切除增生的牙龈组织，并让患者定期进行维护。术后一年的随访显示牙龈有轻微生长。
