1977年分离出的多重耐药肺炎链球菌“明尼苏达”菌株中与转座子Tn1545同源的核苷酸序列的DNA杂交研究。

DNA hybridization studies of a nucleotide sequence homologous to transposon Tn1545 in the "Minnesota" strain of multiresistant Streptococcus pneumoniae isolated in 1977.

作者信息

Cooksey R C, Swenson J M, Clark N C, Thornsberry C

机构信息

Antimicrobics Investigations Branch, Centers for Disease Control, Atlanta, Georgia 30333.

出版信息

Diagn Microbiol Infect Dis. 1989 Jan-Feb;12(1):13-6. doi: 10.1016/0732-8893(89)90038-2.

DOI:10.1016/0732-8893(89)90038-2

PMID:2540933

Abstract

Nucleotide sequences homologous to the transposon-specific region and the tetM determinant mediating tetracycline resistance of the multiresistance transposon Tn1545, originating in Streptococcus pneumoniae, were detected by hybridization in the first multiresistant pneumococcus reported in the United States. The sequences were localized to a common 25-kb EcoRI restriction fragment of the chromosome.

摘要

在美国报道的首例多重耐药肺炎球菌中，通过杂交检测到了与转座子特异性区域以及介导多重耐药转座子Tn1545四环素耐药性的tetM决定簇同源的核苷酸序列。这些序列定位于染色体上一个常见的25kb EcoRI限制性片段。