Institute of Pharmaceutical Science, King's College London , Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.
Langmuir. 2014 Dec 16;30(49):14999-5008. doi: 10.1021/la5038475. Epub 2014 Dec 1.
A novel, fast, and easy mechano-chemistry-based (dry milling) method has been developed to exfoliate graphene with hydrophobic drugs generating few-layer graphene mesosheets (< 10 nm in thickness and ∼1 μm in width). The electronic properties of the graphitic structure were partially preserved after the milling treatment compared with graphene oxide prepared by Hummers' method. Several characterization techniques such as thermogravimetric analysis, Raman spectroscopy, atomic force microscopy, electron microscopy, and molecular dynamics simulation were used to characterize this material. The drug-exfoliated mesosheets were pharmacologically inactive, offering a new approach for making water-soluble few-layer graphene mesosheets upon dry milling with hydrophobic drugs, mainly used as exfoliating agents.
一种新颖、快速且简便的基于机械化学（干法研磨）的方法已经被开发出来，用于剥离具有疏水性药物的石墨烯，生成少层石墨烯介孔片（厚度<10nm 且宽度约 1μm）。与通过 Hummers 方法制备的氧化石墨烯相比，研磨处理后石墨结构的电子性质部分得到了保留。使用了多种表征技术，如热重分析、拉曼光谱、原子力显微镜、电子显微镜和分子动力学模拟，来对这种材料进行了表征。药物剥离的介孔片没有药理活性，为通过干法研磨用疏水性药物制备水溶性少层石墨烯介孔片提供了一种新方法，主要用作剥离剂。
