Regional and developmental estimations of glycerophosphorylcholine phosphodiesterase activities in rat brain.

The activity of glycerophosphorylcholine phosphodiesterases was determined in the mesencephalon, diencephalon, cerebral hemispheres, cerebellum and olfactory bulb during postnatal development from P5 to P70 of rat brain. These activities are low and gradually increase to near adult levels by the end of the first postnatal month similar to that for CNPase activity. This is in accord with glycerophosphorylcholine choline phosphate phosphodiesterase being present in the myelin membrane.