从单一胰岛自身抗体进展为多种胰岛自身抗体的情况通常在血清转化后不久就会出现：对早期筛查的启示。 - Suppr

Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening.

作者信息

Chmiel Ruth, Giannopoulou Eleni Z, Winkler Christiane, Achenbach Peter, Ziegler Anette-Gabriele, Bonifacio Ezio

机构信息

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.

出版信息

Diabetologia. 2015 Feb;58(2):411-3. doi: 10.1007/s00125-014-3443-1. Epub 2014 Nov 20.

DOI:10.1007/s00125-014-3443-1

PMID:25409656

Abstract

摘要

相似文献

Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening.从单一胰岛自身抗体进展为多种胰岛自身抗体的情况通常在血清转化后不久就会出现：对早期筛查的启示。

Diabetologia. 2015 Feb;58(2):411-3. doi: 10.1007/s00125-014-3443-1. Epub 2014 Nov 20.

Diabetologia. 2012 Jul;55(7):1937-43. doi: 10.1007/s00125-012-2472-x.

Islet-cell and insulin autoantibodies in first-degree relatives of type I diabetics: a 5-year follow-up study in a Swiss population.1型糖尿病患者一级亲属中的胰岛细胞抗体和胰岛素自身抗体：瑞士人群的一项5年随访研究。

Adv Exp Med Biol. 1988;246:209-14. doi: 10.1007/978-1-4684-5616-5_25.

Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.自身抗体对IA-2表位的早期产生及扩散及其与1型糖尿病进展的关联。

J Immunol. 1998 Dec 15;161(12):6963-9.

Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes.1型糖尿病风险增加儿童的胰岛自身抗体表型及发病率

Diabetologia. 2015 Oct;58(10):2317-23. doi: 10.1007/s00125-015-3672-y. Epub 2015 Jul 3.

Insulin autoantibodies in pre-diabetes.糖尿病前期的胰岛素自身抗体

Adv Exp Med Biol. 1988;246:45-51. doi: 10.1007/978-1-4684-5616-5_6.

Immunoreactivity to a 64,000 Mr human islet cell antigen in sera from insulin-dependent diabetes mellitus patients and individuals with abnormal glucose tolerance.胰岛素依赖型糖尿病患者及糖耐量异常个体血清中对64,000 Mr人胰岛细胞抗原的免疫反应性。

Mol Biol Med. 1986 Apr;3(2):137-42.

Concordance between twins for beta-cell autoimmunity.双胞胎之间β细胞自身免疫的一致性。

Diabetes. 1996 Sep;45(9):1284. doi: 10.2337/diab.45.9.1284.

Epstein-Barr virus infection is not associated with islet cell and insulin auto-antibody seroconversion.爱泼斯坦-巴尔病毒感染与胰岛细胞及胰岛素自身抗体血清转化无关。

Diabetologia. 1995 Sep;38(9):1130. doi: 10.1007/BF00402187.

Complement-fixing islet-cell antibodies before and after onset of insulin-dependent diabetes.胰岛素依赖型糖尿病发病前后的补体结合胰岛细胞抗体。

Lancet. 1980 Oct 11;2(8198):805. doi: 10.1016/s0140-6736(80)90422-5.

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Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening.1型糖尿病的危险因素、风险预测及症状前检测：筛查的证据与指南

Diabetes Obes Metab. 2025 Mar 25. doi: 10.1111/dom.16354.

ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes.《国际儿童青少年糖尿病研究学会（ISPAD）2024年临床实践共识指南：1型糖尿病儿童和青少年的筛查、分期及保留β细胞功能的策略》

Horm Res Paediatr. 2024;97(6):529-545. doi: 10.1159/000543035. Epub 2024 Dec 11.

Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases.炎症增加以及内质网应激和翻译减少可区分1型糖尿病症状前期1期的胰岛与非糖尿病病例。

bioRxiv. 2024 Sep 19:2024.09.13.612933. doi: 10.1101/2024.09.13.612933.

General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study).在学龄前疫苗接种时使用胰岛自身抗体进行 1 型糖尿病的一般人群筛查：概念验证研究（T1Early 研究）。

Arch Dis Child. 2024 Sep 25;109(10):812-817. doi: 10.1136/archdischild-2023-326697.

Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes.胰岛自身抗体阳性的 3 期 1 型糖尿病前期患者监测的共识指导。

Diabetes Care. 2024 Aug 1;47(8):1276-1298. doi: 10.2337/dci24-0042.

Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes.胰岛自身抗体阳性的 3 期 1 型糖尿病前阶段患者监测的共识指南。

Diabetologia. 2024 Sep;67(9):1731-1759. doi: 10.1007/s00125-024-06205-5.

Beyond Stages: Predicting Individual Time Dependent Risk for Type 1 Diabetes.超越阶段：预测 1 型糖尿病个体随时间变化的风险。

J Clin Endocrinol Metab. 2024 Nov 18;109(12):3211-3219. doi: 10.1210/clinem/dgae292.

Glucagon-like peptide-1 receptor agonists as a possible intervention to delay the onset of type 1 diabetes: A new horizon.胰高血糖素样肽-1受体激动剂作为延缓1型糖尿病发病的一种可能干预措施：新的前景。

World J Diabetes. 2024 Feb 15;15(2):133-136. doi: 10.4239/wjd.v15.i2.133.

Screening and Prevention of Type 1 Diabetes: Where Are We?1 型糖尿病的筛查与预防：我们现在处于什么位置？

J Clin Endocrinol Metab. 2023 Nov 17;108(12):3067-3079. doi: 10.1210/clinem/dgad328.

Secondary Prevention of Diabetes Type 1 with Oral Calcitriol and Analogs, the PRECAL Study.口服骨化三醇及其类似物对1型糖尿病的二级预防：PRECAL研究

Children (Basel). 2023 May 11;10(5):862. doi: 10.3390/children10050862.

本文引用的文献

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.多种胰岛自身抗体的血清转化与儿童糖尿病进展的风险。

JAMA. 2013 Jun 19;309(23):2473-9. doi: 10.1001/jama.2013.6285.

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk.早期血清转化和快速增加的自身抗体浓度可预测遗传风险儿童的 1 型糖尿病青春期前发病。

Diabetologia. 2012 Jul;55(7):1926-36. doi: 10.1007/s00125-012-2523-3. Epub 2012 Mar 23.

Diabetologia. 2012 Jul;55(7):1937-43. doi: 10.1007/s00125-012-2472-x.

Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study.降低高危儿童发生 1 型糖尿病的胰岛自身免疫风险的初级饮食干预研究：BABYDIET 研究。

Diabetes Care. 2011 Jun;34(6):1301-5. doi: 10.2337/dc10-2456. Epub 2011 Apr 22.

Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents.简短通讯：胰岛自身抗体的早期出现可预测糖尿病父母后代患儿童1型糖尿病的风险

Ann Intern Med. 2004 Jun 1;140(11):882-6. doi: 10.7326/0003-4819-140-11-200406010-00009.

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Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening.

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