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Bronchial extracellular matrix from COPD patients induces altered gene expression in repopulated primary human bronchial epithelial cells.COPD 患者的支气管细胞外基质诱导再殖原代人支气管上皮细胞基因表达改变。
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Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.气道细菌在缺乏聚合免疫球蛋白受体的小鼠中引发类似慢性阻塞性肺疾病（COPD）的进行性表型。
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Malondialdehyde-Acetaldehyde Adduct Formation Decreases Immunoglobulin A Transport across Airway Epithelium in Smokers Who Abuse Alcohol.丙二醛-乙醛加合物的形成会降低嗜烟酗酒者呼吸道上皮细胞免疫球蛋白 A 的转运。
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A study on the mechanism of agonists in regulating transcriptional level of pIgR in salivary gland epithelial cells.激动剂调节唾液腺上皮细胞中pIgR转录水平的机制研究。
Exp Ther Med. 2018 Dec;16(6):4367-4372. doi: 10.3892/etm.2018.6792. Epub 2018 Sep 25.
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Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules.泛素及泛素样分子修饰对细胞抗病毒信号传导的调控
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本文引用的文献

1
A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD.系统生物学方法揭示了啮齿动物吸烟模型和人类 COPD 中系统性细胞因子与骨骼肌能量代谢之间的联系。
Genome Med. 2014 Aug 9;6(8):59. doi: 10.1186/s13073-014-0059-5. eCollection 2014.
2
Effectiveness of the Assessment of Burden of Chronic Obstructive Pulmonary Disease (ABC) tool: study protocol of a cluster randomised trial in primary and secondary care.评估慢性阻塞性肺疾病负担（ABC）工具的有效性：一项在初级和二级保健中进行的群组随机试验研究方案。
BMC Pulm Med. 2014 Aug 7;14:131. doi: 10.1186/1471-2466-14-131.
3
Polymeric immunoglobulin receptor down-regulation in chronic obstructive pulmonary disease. Persistence in the cultured epithelium and role of transforming growth factor-β.聚合物免疫球蛋白受体在慢性阻塞性肺疾病中的下调。在培养的上皮细胞中的持续存在和转化生长因子-β的作用。
Am J Respir Crit Care Med. 2014 Sep 1;190(5):509-21. doi: 10.1164/rccm.201311-1971OC.
4
Management, morbidity and mortality of COPD during an 11-year period: an observational retrospective epidemiological register study in Sweden (PATHOS).11年间慢性阻塞性肺疾病的管理、发病率和死亡率：瑞典的一项观察性回顾性流行病学登记研究（PATHOS）
Prim Care Respir J. 2014 Mar;23(1):38-45. doi: 10.4104/pcrj.2013.00106.
5
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.多免疫球蛋白受体在炎症诱导的人肝癌肿瘤转移中的作用。
J Natl Cancer Inst. 2011 Nov 16;103(22):1696-712. doi: 10.1093/jnci/djr360. Epub 2011 Oct 24.
6
Secretory IgA and COPD: a new kid on the block?分泌型免疫球蛋白A与慢性阻塞性肺疾病：新成员？
Am J Respir Crit Care Med. 2011 Aug 1;184(3):285-7. doi: 10.1164/rccm.201105-0821ED.
7
Dual effect of neutrophils on pIgR/secretory component in human bronchial epithelial cells: role of TGF-beta.中性粒细胞对人支气管上皮细胞中多聚免疫球蛋白受体/分泌成分的双重作用：转化生长因子-β的作用
J Biomed Biotechnol. 2010;2010. doi: 10.1155/2010/428618. Epub 2010 Jul 8.
8
Regulation of polymeric immunoglobulin receptor expression by reovirus.呼肠孤病毒对聚合免疫球蛋白受体表达的调节
J Gen Virol. 2005 Aug;86(Pt 8):2347-2357. doi: 10.1099/vir.0.80690-0.
9
Up-regulation of polymeric immunoglobulin receptor mRNA in mammary epithelial cells by IFN-gamma.γ干扰素对乳腺上皮细胞中聚合免疫球蛋白受体mRNA的上调作用。
Mol Cell Endocrinol. 2002 Aug 30;194(1-2):95-105. doi: 10.1016/s0303-7207(02)00183-1.
10
Reduced epithelial expression of secretory component in small airways correlates with airflow obstruction in chronic obstructive pulmonary disease.小气道中分泌成分的上皮表达降低与慢性阻塞性肺疾病中的气流阻塞相关。
Am J Respir Crit Care Med. 2001 Jan;163(1):185-94. doi: 10.1164/ajrccm.163.1.9912137.

Does pIgR down-regulation in COPD cause reprogramming of bronchial epithelium?

作者信息

Sankineni Spoorthi, Cho Young, Hosseinian Nima, Kolliputi Narasaiah

机构信息

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 19, Tampa, FL, 33612, USA.

出版信息

Lung. 2015 Feb;193(1):1-2. doi: 10.1007/s00408-014-9668-4. Epub 2014 Nov 20.

DOI:10.1007/s00408-014-9668-4
PMID:25409937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4320649/
Abstract
摘要