Yao Yaping, Xin Ruolei, Yang Jiezhe, Xu Yun, Zhang Jiafeng, Xia Yan, Pan Xiaohong, Guo Zhihong, Song Yanhui
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People's Republic of China.
Virus Genes. 2015 Feb;50(1):22-8. doi: 10.1007/s11262-014-1136-y. Epub 2014 Nov 20.
The epidemic characteristics of human immunodeficiency virus type 1 (HIV-1) in Zhejiang Province have not been systematically identified. This study presented a dynamic analysis of HIV-1 subtype variation in Zhejiang from 2004 to 2008, based on the surveillance of molecular epidemiology or drug resistance. CRF01_AE was the major strain (43.5 %) spreading across the province, second by B/B' (17.9 %), CRF07_BC (17.1 %), and CRF08_BC (13.7 %). The strains were mainly transmitted by heterosexual contact. Novel recombinant strains and vertical transmission were occasionally reported. Floating population from other provinces accounted for a significant number of HIV-1 cases in Zhejiang. These data may provide us rational intervention strategy for further control of HIV dissemination.
浙江省人类免疫缺陷病毒1型（HIV-1）的流行特征尚未得到系统鉴定。本研究基于分子流行病学或耐药性监测，对2004年至2008年浙江省HIV-1亚型变异进行了动态分析。CRF01_AE是全省传播的主要毒株（43.5%），其次是B/B'（17.9%）、CRF07_BC（17.1%）和CRF08_BC（13.7%）。这些毒株主要通过异性接触传播。偶尔报告有新型重组毒株和垂直传播情况。来自其他省份的流动人口在浙江省HIV-1病例中占相当数量。这些数据可为我们进一步控制HIV传播提供合理的干预策略。
