Wang David
Departments of Molecular Microbiology and Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
J Virol. 2015 Feb;89(3):1486-8. doi: 10.1128/JVI.01194-14. Epub 2014 Nov 19.
The advent of high-throughput sequencing has led to a tremendous increase in the rate of discovery of viral sequences. In some instances, novel pathogens have been identified. What has been less well appreciated is that novel virus discoveries in distinct hosts have led to the establishment of unique experimental systems to define host-virus interactions. These new systems have opened new frontiers in the study of fundamental virology and infectious disease.
高通量测序技术的出现极大地提高了病毒序列的发现速度。在某些情况下,新型病原体得以被识别。然而,人们尚未充分认识到的是,在不同宿主中发现新型病毒促使建立了独特的实验系统来界定宿主与病毒的相互作用。这些新系统为基础病毒学和传染病研究开辟了新的领域。