镉对硒、锌、铁、钴和铷组织水平的影响。

Effect of Cd on tissue levels of Se, Zn, Fe, Co and Rb.

作者信息

Czauderna M, Rochalska M

机构信息

Department of Chemistry, Warsaw University, Poland.

出版信息

Int J Rad Appl Instrum A. 1989;40(2):177-81. doi: 10.1016/0883-2889(89)90195-0.

DOI:10.1016/0883-2889(89)90195-0

PMID:2541107

Abstract

The interaction of Cd (as CdCl2) with organic Se-compounds and SeO2 was investigated. Instrumental neutron activation analysis was applied as the analytical method. Concentrations of Se in liver and kidneys were always significantly higher after simultaneous i.p. injections with Cd and Se-compounds in comparison with single Se-injection. Cd or Se-injections also affect the content of Zn, Fe, Co and Rb in all the investigated organs. We suggested that the formation of Cd-Se-protein complexes allow for an orderly transfer of Cd to metallothionein (MT). The results showed that Cd was a very effective inducer of MT, and the maximum formation of MT was observed in the liver.

摘要

研究了镉（以氯化镉形式）与有机硒化合物及二氧化硒之间的相互作用。采用仪器中子活化分析作为分析方法。与单次注射硒相比，腹腔内同时注射镉和硒化合物后，肝脏和肾脏中的硒浓度总是显著更高。注射镉或硒也会影响所有被研究器官中锌、铁、钴和铷的含量。我们认为，镉 - 硒蛋白复合物的形成使得镉能够有序地转移至金属硫蛋白（MT）。结果表明，镉是金属硫蛋白的一种非常有效的诱导剂，并且在肝脏中观察到金属硫蛋白的最大生成量。