• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The antiviral activity of dideoxycytidine.

作者信息

Jeffries D J

机构信息

Division of Virology, St. Mary's Hospital Medical School, Paddington, London, UK.

出版信息

J Antimicrob Chemother. 1989 Jan;23 Suppl A:29-34. doi: 10.1093/jac/23.suppl_a.29.

DOI:10.1093/jac/23.suppl_a.29
PMID:2541126
Abstract

2',3'-Dideoxycytidine (ddc) is a 2',3'-dideoxypyrimidine nucleotide which has been shown to be active against human immunodeficiency virus type 1 (HIV-1) in cell cultures. This article reviews some of the laboratory studies with this antiviral compound, and available pharmacokinetic and toxicity data from phase 1 studies of ddc alone and in alternation with zidovudine in patients with AIDS and ARC. Though ddc has potent activity against HIV-1 in vitro, serious toxic effects seen in phase 1 studies warrant continuation of trials to explore lower dosage regimens, alternation with zidovudine and intermittent therapy.

摘要

相似文献

1
The antiviral activity of dideoxycytidine.
J Antimicrob Chemother. 1989 Jan;23 Suppl A:29-34. doi: 10.1093/jac/23.suppl_a.29.
2
Human immunodeficiency virus inhibition is prolonged by 3'-azido-3'-deoxythymidine alternating with 2',3'-dideoxycytidine compared with 3'-azido-3'-deoxythymidine alone.与单独使用3'-叠氮-3'-脱氧胸苷相比，3'-叠氮-3'-脱氧胸苷与2',3'-二脱氧胞苷交替使用可延长对人类免疫缺陷病毒的抑制作用。
Antimicrob Agents Chemother. 1989 Jun;33(6):920-3. doi: 10.1128/AAC.33.6.920.
3
Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.叠氮胸苷及相关的2'，3'-双脱氧核苷对新鲜的和培养的人外周血单核细胞/巨噬细胞中人类免疫缺陷病毒（HIV-1/HTLV-IIIBa-L）复制的抑制作用
J Exp Med. 1988 Sep 1;168(3):1111-25. doi: 10.1084/jem.168.3.1111.
4
Pharmacokinetic evaluation of drug interactions with anti-human immunotrophic virus (HIV) Drugs. III. 2',3'-Dideoxycytidine (ddC) and zidovudine in monkeys.
Pharm Res. 1992 Feb;9(2):224-7. doi: 10.1023/a:1018941507979.
5
Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides.立体化学对双脱氧胞苷核苷抗病毒活性及耐药性的影响。
Antimicrob Agents Chemother. 1994 Apr;38(4):868-71. doi: 10.1128/AAC.38.4.868.
6
Decreased anti-human immunodeficiency virus type-1 activities of 2',3'-dideoxynucleoside analogs in MOLT-4 cell sublines resistant to 2',3'-dideoxynucleoside analogs.
Acta Virol. 1993 Oct;37(5):360-8.
7
Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine.用抗人免疫缺陷病毒化合物2'，3'-二脱氧胞苷处理的细胞中出现延迟性细胞毒性和线粒体DNA的选择性丢失。
J Biol Chem. 1989 Jul 15;264(20):11934-7.
8
Pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS and related disorders.艾滋病及相关疾病患者中2',3'-双脱氧胞苷的药代动力学
J Clin Pharmacol. 1988 Sep;28(9):837-42. doi: 10.1002/j.1552-4604.1988.tb03225.x.
9
Pharmacodynamics of 2',3'-dideoxycytidine: an inhibitor of human immunodeficiency virus.
Am J Med. 1990 May 21;88(5B):2S-7S. doi: 10.1016/0002-9343(90)90413-8.
10
In vitro antiviral activity of didanosine compared with that of other dideoxynucleoside analogs against laboratory strains and clinical isolates of human immunodeficiency virus.
Clin Infect Dis. 1993 Feb;16 Suppl 1:S16-21. doi: 10.1093/clinids/16.supplement_1.s16.

引用本文的文献

1
Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase.伊利马醌，一种人类免疫缺陷病毒1型逆转录酶核糖核酸酶H活性的选择性抑制剂。
Antimicrob Agents Chemother. 1990 Oct;34(10):2009-12. doi: 10.1128/AAC.34.10.2009.