Kruizinga Pieter, van der Steen Antonius F W, de Jong Nico, Springeling Geert, Robertus Jan Lukas, van der Lugt Aad, van Soest Gijs
Erasmus Medical Center, Thorax Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Erasmus Medical Center, Thorax Center, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsbDelft University of Technology, Faculty Applied Sciences, P.O. Box 5, 2600 AA, Delft, The NetherlandscInteruniversity Cardiology Institute of The Netherlands, P.O. Bo.
J Biomed Opt. 2014 Nov;19(11):110504. doi: 10.1117/1.JBO.19.11.110504.
We introduce a method for photoacoustic imaging of the carotid artery, tailored toward detection of lipid-rich atherosclerotic lesions. A common human carotid artery was obtained at autopsy, embedded in a neck mimicking phantom and imaged with a multimodality imaging system using interstitial illumination. Light was delivered through a 1.25-mm-diameter optical probe that can be placed in the pharynx, allowing the carotid artery to be illuminated from within the body. Ultrasound imaging and photoacoustic signal detection is achieved by an external 8-MHz linear array coupled to an ultrasound imaging system. Spectroscopic analysis of photoacoustic images obtained in the wavelength range from 1130 to 1250 nm revealed plaque-specific lipid accumulation in the collagen structure of the artery wall. These spectroscopic findings were confirmed by histology.
我们介绍了一种针对富含脂质的动脉粥样硬化病变检测的颈动脉光声成像方法。在尸检时获取一条普通人类颈动脉，将其嵌入模拟颈部的体模中，并使用多模态成像系统通过组织间照明进行成像。光通过一个直径为1.25毫米的光学探头传输，该探头可放置在咽部，从而能够从体内照亮颈动脉。超声成像和光声信号检测由与超声成像系统耦合的外部8兆赫线性阵列实现。对在1130至1250纳米波长范围内获得的光声图像进行光谱分析，揭示了动脉壁胶原结构中斑块特异性脂质积累。这些光谱学发现得到了组织学的证实。
