迈向颈动脉易损斑块的体内光声成像。
Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery.
作者信息
Muller Jan-Willem, van Hees Roy, van Sambeek Marc, Boutouyrie Pierre, Rutten Marcel, Brands Peter, Wu Min, Lopata Richard
机构信息
Photoacoustics and Ultrasound Laboratory Eindhoven (PULS/e), Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands.
出版信息
Biomed Opt Express. 2021 Jun 17;12(7):4207-4218. doi: 10.1364/BOE.430064. eCollection 2021 Jul 1.
Abstract
The main indicator for endarterectomy is the grade of stenosis, which results in severe overtreatment. Photoacoustic imaging (PAI) can provide patient-specific assessment of plaque morphology, and thereby vulnerability. A pilot study of PAI on carotid plaques in patients (n=16) was performed intraoperatively with a hand-held PAI system. By compensating for motion, the photoacoustic (PA) signal-to-noise ratio (SNR) could be increased by 5 dB in vivo. PA signals from hemorrhagic plaques had different characteristics compared to the signals from the carotid blood pool. This study is a key step towards a non-invasive application of PAI to detect vulnerable plaques.
摘要
动脉内膜切除术的主要指标是狭窄程度，这导致了严重的过度治疗。光声成像（PAI）可以提供针对患者的斑块形态评估，从而评估其易损性。使用手持式PAI系统对16例患者的颈动脉斑块进行了术中PAI初步研究。通过补偿运动，体内光声（PA）信噪比（SNR）可提高5 dB。出血性斑块的PA信号与颈动脉血池的信号具有不同的特征。这项研究是PAI无创检测易损斑块应用的关键一步。
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