Klin Baruch, Efrati Yigal, Berkovitch Matitiahu, Abu-Kishk Ibrahim
Pediatric Division, Assaf HaRofeh Medical Center, Tzrifin, Israel -
Minerva Pediatr. 2016 Jun;68(3):196-200. Epub 2014 Nov 20.
We aimed to evaluate efficacy and safety of the use of nifedipine gel with lidocaine in the treatment of acute anal fissures in children by reviewing the cases of 106 children with acute anal fissure treated conservatively by nifedipine gel with lidocaine between the years 2003-2012.
The patients included in this study were 48 males and 58 females. Their clinical presentation consisted of constipation, rectal bleeding, anal pain, perianal itching, abdominal pain, irritability and rectal prolapse. Posterior, anterior, both anterior and posterior, multiple, both posterior and lateral locations were the main physical findings in 65, 23, 10, 7, and 1 cases.
Ninety-nine patients completed the 4-week treatment course of nifedipine gel with lidocaine successfully (93.40%), with complete healing of the fissure. The recurrence rate observed was very low (6.60%).
Topical 0.2% nifedipine with lidocaine appears an efficient mode of treatment for anal fissures in children, with a significant healing rate and no side effects.
通过回顾2003年至2012年间106例使用利多卡因硝苯地平凝胶保守治疗的儿童急性肛裂病例，我们旨在评估利多卡因硝苯地平凝胶治疗儿童急性肛裂的疗效和安全性。
本研究纳入的患者中男性48例，女性58例。他们的临床表现包括便秘、直肠出血、肛门疼痛、肛周瘙痒、腹痛、易怒和直肠脱垂。主要体征表现为肛裂位于后侧、前侧、前后侧均有、多发、后侧和侧方均有，分别有65、23、10、7和1例。
99例患者成功完成了为期4周的利多卡因硝苯地平凝胶治疗疗程（93.40%），肛裂完全愈合。观察到的复发率非常低（6.60%）。
局部使用0.2%利多卡因硝苯地平似乎是治疗儿童肛裂的一种有效方法，愈合率高且无副作用。
