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烧伤患者中使用大麻的趋势迅速上升。

The rapidly increasing trend of cannabis use in burn injury.

作者信息

Jehle Charles Christopher, Nazir Niaman, Bhavsar Dhaval

机构信息

From the University of Kansas Medical Center, Kansas City.

出版信息

J Burn Care Res. 2015 Jan-Feb;36(1):e12-7. doi: 10.1097/BCR.0000000000000192.

Abstract

The use of cannabis is currently increasing according to U.S. Department of Health and Human Services (HHS). Surprisingly, cannabis use among burn patients is poorly reported in literature. In this study, rates of cannabis use in burn patients are compared with general population. Data from the National Burn Repository (NBR) were used to investigate incidence, demographics, and outcomes in relation to use of cannabis as evidenced by urine drug screen (UDS). Thousands of patients from the NBR from 2002 to 2011 were included in this retrospective study. Inclusion criteria were patients older than 12 years of age who received a drug screen. Data points analyzed were patients' age, sex, UDS status, mechanism of burn injury, total body surface area, length of stay, ICU days, and insurance characteristics. Incidence of cannabis use in burn patients from the NBR was compared against national general population rates (gathered by Health and Human Services) using chi-square tests. Additionally, the burn patient population was analyzed using bivariate analysis and t-tests to find differences in the characteristics of these patients as well as differences in outcomes. Seventeen thousand eighty out of over 112,000 patients from NBR had information available for UDS. The incidence of cannabis use is increasing among the general population, but the rate is increasing more quickly among patients in the burn patient population (P = .0022). In 2002, 6.0% of patients in burn units had cannabis+ UDS, which was comparable with national incidence of 6.2%. By 2011, 27.0% of burn patients tested cannabis+ while national incidence of cannabis use was 7.0%. Patients who test cannabis+ are generally men (80.1%, P < .0001) and are younger on average (35 years old vs 42, P < .0001). The most common mechanisms of injury among patients who test cannabis+ or cannabis- are similar. Flame injury makes up >60% of injuries, followed by scalds that are >15%. In comparing cannabis+/- patients, cannabis+ patients are more likely to be uninsured (25.2% vs 17.26%, P < .0001). Finally, patients who test cannabis+ have larger burns (TBSA% of 12.94 vs 10.98, P < .0001), have a longer length of stay (13.31 days vs 12.6, P = .16), spend more days in the ICU (7.84 vs 6.39, P = .0006), and have more operations (2.78 vs 2.05, P < .0001). The rate patients testing positive for cannabis in burn units is growing quickly. These patients are younger and are less likely to be insured. These patients also have larger burns, spend more time in ICUs, and have a greater number of operations. The increasing use of cannabis, as expected from legalization of cannabis in multiple states, among burn patient population may lead to increased burden on already tenuous health care resources.

摘要

根据美国卫生与公众服务部(HHS)的数据,大麻的使用量目前正在上升。令人惊讶的是,文献中关于烧伤患者使用大麻的报道很少。在本研究中,将烧伤患者的大麻使用率与普通人群进行了比较。利用国家烧伤资料库(NBR)的数据,研究了与尿液药物筛查(UDS)所证实的大麻使用相关的发病率、人口统计学特征及预后情况。本回顾性研究纳入了2002年至2011年NBR中的数千名患者。纳入标准为年龄大于12岁且接受了药物筛查的患者。分析的数据点包括患者的年龄、性别、UDS状态、烧伤机制、烧伤总面积、住院时间、重症监护病房(ICU)天数以及保险特征。使用卡方检验将NBR中烧伤患者的大麻使用发病率与全国普通人群发病率(由卫生与公众服务部收集)进行比较。此外,采用双变量分析和t检验对烧伤患者群体进行分析,以找出这些患者特征以及预后方面的差异。NBR中超过112,000名患者中有17,080名患者有UDS相关信息。普通人群中大麻使用的发病率在上升,但烧伤患者群体中的上升速度更快(P = 0.0022)。2002年,烧伤病房中6.0%的患者UDS检测显示大麻阳性,这与全国6.2%的发病率相当。到2011年,27.0%的烧伤患者大麻检测呈阳性,而全国大麻使用发病率为7.0%。大麻检测呈阳性的患者通常为男性(80.1%;P < 0.0001),且平均年龄更小(35岁对42岁;P < 0.0001)。大麻检测呈阳性或阴性的患者中最常见的损伤机制相似。火焰伤占损伤的比例超过60%,其次是烫伤,占比超过15%。在比较大麻阳性/阴性患者时,大麻阳性患者更有可能未参保(25.2%对17.26%;P < 0.0001)。最后大麻检测呈阳性的患者烧伤面积更大(烧伤总面积百分比为12.94对10.98;P < 0.0001),住院时间更长(13.31天对12.6天;P = 0.16),在ICU的天数更多(7.84天对6.39天;P = 0.0006),且手术次数更多(2.78次对2.05次;P < 0.0001)。烧伤病房中大麻检测呈阳性的患者比例正在迅速上升。这些患者更年轻,且参保可能性更低。这些患者烧伤面积也更大,在ICU的时间更长,手术次数更多。正如多个州大麻合法化所预期的那样,烧伤患者群体中大麻使用的增加可能会给本就脆弱的医疗资源带来更大负担。

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