Santaniello John M, Luchette Fred A, Esposito Thomas J, Gunawan Henry, Reed R Lawrence, Davis Kimberly A, Gamelli Richard L
Division of Trauma, Critical Care and Burns, Loyola University Medical Center, Maywood, Illinois 60153, USA.
J Trauma. 2004 Oct;57(4):696-700; dicussion 700-1. doi: 10.1097/01.ta.0000140480.50079.a8.
Percent total body surface area (TBSA) burn, inhalation injury (INH), and age all have been shown to be independent predictors of mortality in burn victims. Little is known regarding patients sustaining combined thermal and mechanical injuries in relation to either injury sustained in isolation or with regard to these variables. This descriptive study profiles the 10-year experience of a single American Burn Association/American College of Surgeons verified Level I trauma and burn center and the treatment of this patient population.
A retrospective review of all burn and trauma patients admitted between 1990 and 2000. Patients were divided into three groups; Burn only (B), Trauma only (T), and combined Burn/Trauma (B/T). Groups were compared with respect to age, TBSA burn, length of stay (LOS), Injury Severity Score (ISS), INH and mortality. These groups were then compared with B, T and B/T patients from the National Burn Repository (NBR) and National Trauma Data Bank (NTDB). Student's t test and chi tests were performed, as well as multiple logistic regression to identify independent predictors of mortality. p <0.05 was considered significant.
Through our trauma registry, 24,093 patients were identified (T=22,284, B=1717 and B/T=92). When comparing B and T, there was no difference in age, LOS, ISS, or mortality to those patients in the NBR or NTDB. B/T patients showed significantly increased percentage with INH (B/T=44.5% versus 11%), increased LOS (B/T=18 days versus 13.7 B and 5.3 T) and increased mortality (B/T=28.3% versus 9.8% B and 4.3% T). B/T were also significantly older (B/T=40.1 years versus 31.0 B and 35.1 T). When these variables are compared with the NBR and the NTDB benchmarks, mortality (28.3% versus 11.6% NBR and 7.0% NTDB) and ISS (23 versus 11.7 NTDB) were significantly higher with no difference in age (40.1 versus 33.4 NTDB, 35.9 NBR), LOS (18 days versus 23.3 NBR) or TBSA (20.8% versus 19.5% NBR). Multiple logistic regression comparing TBSA, age, ISS and INH of survivors versus non-survivors identified only ISS as an independent predictor of mortality.
B combined with T presents a rare injury pattern that has a synergistic effect on mortality. Physicians and caregivers should be aware of a 2-3 fold increase in the incidence of INH in this population, and increased mortality despite similar TBSA burned when compared with patients with B as the sole mechanism; ISS appears to be an independent predictor of mortality in this combined injury pattern.
烧伤患者的总体表面积(TBSA)烧伤百分比、吸入性损伤(INH)和年龄均已被证明是死亡率的独立预测因素。对于遭受热损伤和机械损伤合并伤的患者,与单独遭受其中一种损伤的患者相比,或者与这些变量相关的情况,我们了解得很少。这项描述性研究概述了一家经美国烧伤协会/美国外科医师学会认证的一级创伤和烧伤中心10年的经验以及对这类患者群体的治疗情况。
对1990年至2000年间收治的所有烧伤和创伤患者进行回顾性研究。患者分为三组:单纯烧伤组(B)、单纯创伤组(T)和烧伤/创伤合并组(B/T)。比较三组患者的年龄、TBSA烧伤面积、住院时间(LOS)、损伤严重程度评分(ISS)、INH和死亡率。然后将这些组与来自国家烧伤资料库(NBR)和国家创伤数据库(NTDB)的B、T和B/T患者进行比较。进行了学生t检验和卡方检验,以及多因素逻辑回归分析以确定死亡率的独立预测因素。p<0.05被认为具有统计学意义。
通过我们的创伤登记系统,共识别出24,093例患者(T = 22,284例,B = 1717例,B/T = 92例)。比较B组和T组时,其年龄、LOS、ISS或死亡率与NBR或NTDB中的患者无差异。B/T组患者的INH发生率显著增加(B/T = 44.5%,而B组为11%),住院时间延长(B/T = 18天,B组为13.7天,T组为5.3天),死亡率增加(B/T = 28.3%,B组为9.8%,T组为4.3%)。B/T组患者的年龄也显著更大(B/T = 40.1岁,B组为31.0岁,T组为35.1岁)。当将这些变量与NBR和NTDB的基准进行比较时,死亡率(28.3%,而NBR为11.6%,NTDB为7.0%)和ISS(23,而NTDB为11.7)显著更高,年龄(40.1岁,而NTDB为33.4岁,NBR为35.9岁)、住院时间(18天,而NBR为23.3天)或TBSA(20.8%,而NBR为19.5%)无差异。对幸存者和非幸存者的TBSA烧伤面积、年龄、ISS和INH进行多因素逻辑回归分析,结果仅显示ISS是死亡率的独立预测因素。
B合并T呈现出一种罕见的损伤模式,对死亡率具有协同作用。医生和护理人员应意识到该人群中INH发生率增加了2至3倍,并且与仅以B为单一损伤机制的患者相比,尽管TBSA烧伤面积相似,但死亡率仍有所增加;ISS似乎是这种合并损伤模式下死亡率的独立预测因素。