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Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis.

作者信息

Finucane Orla M, Reynolds Clare M, McGillicuddy Fiona C, Harford Karen A, Morrison Martine, Baugh John, Roche Helen M

机构信息

Institute of Molecular Medicine, School of Medicine, Trinity Centre for Health Sciences, St. James Hospital, Dublin 8, Ireland; Nutrigenomics Research Group, School of Public Health & Population Science, UCD Conway Institute, University College Dublin, Dublin 4, Ireland.

Nutrigenomics Research Group, School of Public Health & Population Science, UCD Conway Institute, University College Dublin, Dublin 4, Ireland; Liggins Institute, University of Auckland, Auckland, New Zealand.

出版信息

PLoS One. 2014 Nov 20;9(11):e113369. doi: 10.1371/journal.pone.0113369. eCollection 2014.

DOI:10.1371/journal.pone.0113369
PMID:25412423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4239060/
Abstract

Macrophage infiltration is a critical determinant of high-fat diet induced adipose tissue inflammation and insulin resistance. The precise mechanisms underpinning the initiation of macrophage recruitment and activation are unclear. Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, displays chemokine-like properties. Circulating MIF levels are elevated during obesity however its role in high-fat diet induced adipose inflammation and insulin resistance remains elusive. Wildtype and MIF-/- C57Bl\6J mice were fed chow or high-fat diet. Body weight and food intake was assessed. Glucose homeostasis was monitored by glucose and insulin tolerance tests. Adipose tissue macrophage recruitment and adipose tissue insulin sensitivity was evaluated. Cytokine secretion from stromal vascular fraction, adipose explants and bone marrow macrophages was measured. Inflammatory signature and insulin sensitivity of 3T3-L1-adipocytes co-cultured with wildtype and MIF-/- macrophage was quantified. Hepatic triacylglyceride levels were assessed. MIF-/- exhibited reduced weight gain. Age and weight-matched obese MIF-/- mice exhibited improved glucose homeostasis coincident with reduced adipose tissue M1 macrophage infiltration. Obese MIF-/- stromal vascular fraction secreted less TNFα and greater IL-10 compared to wildtype. Activation of JNK was impaired in obese MIF-/-adipose, concomitant with pAKT expression. 3T3-L1-adipocytes cultured with MIF-/- macrophages had reduced pro-inflammatory cytokine secretion and improved insulin sensitivity, effects which were also attained with MIF inhibitor ISO-1. MIF-/- liver exhibited reduced hepatic triacyglyceride accumulation, enhanced pAKT expression and reduced NFκB activation. MIF deficiency partially protects from high-fat diet induced insulin resistance by attenuating macrophage infiltration, ameliorating adipose inflammation, which improved adipocyte insulin resistance ex vivo. MIF represents a potential therapeutic target for treatment of high-fat diet induced insulin resistance.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/86d61c58055f/pone.0113369.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/44d0b0fc000b/pone.0113369.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/0d8f994d0a76/pone.0113369.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/0eabb6061e50/pone.0113369.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/4b87cd3e20f5/pone.0113369.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/6dace2ceb99c/pone.0113369.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/86d61c58055f/pone.0113369.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/44d0b0fc000b/pone.0113369.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/0d8f994d0a76/pone.0113369.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/0eabb6061e50/pone.0113369.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/4b87cd3e20f5/pone.0113369.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/6dace2ceb99c/pone.0113369.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a56/4239060/86d61c58055f/pone.0113369.g006.jpg

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Reappraisal of Adipose Tissue Inflammation in Obesity.

Adv Exp Med Biol. 2024

[2]
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JCI Insight. 2024-7-8

[3]
Differential Modulation by Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) of Mesenteric Fat and Macrophages and T Cells in Adipose Tissue of Obese / Zucker Rats.

Nutrients. 2024-4-27

[4]
Involvement of the Macrophage Migration Inhibitory Factor (MIF) in Lipedema.

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[5]
Immunometabolism in type 2 diabetes mellitus: tissue-specific interactions.

Arch Med Sci. 2020-1-31

[6]
Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes.

Biomolecules. 2023-6-23

[7]
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Rev Endocr Metab Disord. 2023-10

[8]
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[9]
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[10]
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本文引用的文献

[1]
Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance.

Proc Nutr Soc. 2012-8-22

[2]
Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis.

Immunol Cell Biol. 2011-11-8

[3]
Inflammatory links between obesity and metabolic disease.

J Clin Invest. 2011-6-1

[4]
Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states.

Curr Opin Clin Nutr Metab Care. 2011-7

[5]
Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity.

Proc Natl Acad Sci U S A. 2011-5-2

[6]
Fractalkine is a novel human adipochemokine associated with type 2 diabetes.

Diabetes. 2011-5

[7]
Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.

Diabetes. 2011-4-22

[8]
Insulin resistance, inflammation, and obesity: role of monocyte chemoattractant protein-1 (or CCL2) in the regulation of metabolism.

Mediators Inflamm. 2010-9-23

[9]
Macrophage migration inhibitory factor deficiency leads to age-dependent impairment of glucose homeostasis in mice.

J Endocrinol. 2010-6-21

[10]
CXCL5 drives obesity to diabetes, and further.

Aging (Albany NY). 2009-7-2

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