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巨噬细胞移动抑制因子（MIF）与脂肪性水肿的关系。

Involvement of the Macrophage Migration Inhibitory Factor (MIF) in Lipedema.

作者信息

Vasella Mauro, Wolf Stefan, Francis Eamon C, Grieb Gerrit, Pfister Pablo, Reid Gregory, Bernhagen Jürgen, Lindenblatt Nicole, Gousopoulos Epameinondas, Kim Bong-Sung

机构信息

Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.

Department of Plastic and Reconstructive Surgery, Guys and St Thomas Trust, London SE1 7EH, UK.

出版信息

Metabolites. 2023 Oct 23;13(10):1105. doi: 10.3390/metabo13101105.

DOI:10.3390/metabo13101105
PMID:37887430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10608777/
Abstract

Lipedema is a chronic disorder that mainly affects women. It is often misdiagnosed, and its etiology remains unknown. Recent research indicates an accumulation of macrophages and a shift in macrophage polarization in lipedema. One known protein superfamily that contributes to macrophage accumulation and polarization is the macrophage migration inhibitory factor (MIF) family. MIF-1 and MIF-2 are ubiquitously expressed and also regulate inflammatory processes in adipose tissue. In this study, the expression of MIF-1, MIF-2 and CD74-a common receptor for both cytokines-was analyzed in tissue samples of 11 lipedema and 11 BMI-matched, age-matched and anatomically matched control patients using qPCR and immunohistochemistry (IHC). The mRNA expression of MIF-1 (mean 1.256; SD 0.303; = 0.0485) and CD74 (mean 1.514; SD 0.397; = 0.0097) were significantly elevated in lipedema patients, while MIF-2 expression was unaffected (mean 1.004; SD 0.358; = 0.9718). The IHC analysis corroborated the results for CD74 expression on a cellular level. In conclusion, our results provide first evidence for a potential involvement of the MIF family, presumably via the MIF-1-CD74 axis, in lipedema.

摘要

脂肪性水肿是一种主要影响女性的慢性疾病。它常常被误诊，其病因仍然不明。最近的研究表明，在脂肪性水肿中存在巨噬细胞的积聚以及巨噬细胞极化的转变。已知有助于巨噬细胞积聚和极化的一个蛋白质超家族是巨噬细胞迁移抑制因子（MIF）家族。MIF - 1和MIF - 2广泛表达，并且还调节脂肪组织中的炎症过程。在本研究中，使用定量聚合酶链反应（qPCR）和免疫组织化学（IHC）分析了11例脂肪性水肿患者以及11例体重指数（BMI）匹配、年龄匹配和解剖部位匹配的对照患者的组织样本中MIF - 1、MIF - 2和CD74（这两种细胞因子的共同受体）的表达。脂肪性水肿患者中MIF - 1（平均值1.256；标准差0.303；P = 0.0485）和CD74（平均值1.514；标准差0.397；P = 0.0097）的mRNA表达显著升高，而MIF - 2的表达未受影响（平均值1.004；标准差0.358；P = 0.9718）。免疫组织化学分析在细胞水平上证实了CD74表达的结果。总之，我们的结果首次证明了MIF家族可能通过MIF - 1 - CD74轴参与脂肪性水肿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/e4c94d9910ae/metabolites-13-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/a27eaafe74a8/metabolites-13-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/27377aea3683/metabolites-13-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/85f02adf2d59/metabolites-13-01105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/88969adb5b19/metabolites-13-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/e4c94d9910ae/metabolites-13-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/a27eaafe74a8/metabolites-13-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/27377aea3683/metabolites-13-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/85f02adf2d59/metabolites-13-01105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/88969adb5b19/metabolites-13-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a3/10608777/e4c94d9910ae/metabolites-13-01105-g005.jpg

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