Mahowald M L, Krug H, Halverson P
Department of Medicine, Minneapolis VA Medical Center, MN 55417.
J Rheumatol. 1989 Jan;16(1):60-6.
Murine progressive ankylosis was studied by light and electron microscopy (EM). By light microscopy, the earliest synovial lesion was inflammatory followed by synovial proliferation and cartilage erosions. Later changes included progressive joint ankylosis by fibrosis and ossification of articular and periarticular tissues and new bone proliferation. By EM, synovial cell proliferation and hypertrophy with collagen deposition was seen before the appearance of intracellular and extracellular hydroxyapatite crystals. These pathologic changes are the same as those found in the human spondyloarthropathies. Our EM findings demonstrate that hydroxyapatite crystals appear in the joints of ank/ank mice after the initial inflammatory phase.
通过光学显微镜和电子显微镜（EM）对小鼠进行性关节强硬症进行了研究。光学显微镜观察发现，最早的滑膜病变是炎症，随后是滑膜增生和软骨侵蚀。后期变化包括关节和关节周围组织的纤维化和骨化以及新骨增生导致的进行性关节强硬。电子显微镜观察发现，在细胞内和细胞外羟基磷灰石晶体出现之前，可见滑膜细胞增殖、肥大以及胶原沉积。这些病理变化与人类脊柱关节病中发现的变化相同。我们的电子显微镜研究结果表明，羟基磷灰石晶体在ank/ank小鼠关节的初始炎症期之后出现。
