Sampson H W
Department of Human Anatomy, College of Medicine, Texas A&M University, College Station 77843.
Am J Anat. 1988 Jul;182(3):257-69. doi: 10.1002/aja.1001820307.
The metacarpophalangeal joint of the progressive ankylosis mouse was examined at 4, 6 and 8 weeks of age by using electron microscopy and electron probe microanalysis. These studies describe the progression of the disorder, and they reveal three overlapping phases: pannus proliferation, chondrophyte formation and mineralization, and articular cartilage mineralization. The chondrophyte mineralized in a manner fairly similar to endochondrial bone, whereas articular cartilage mineralized by advancement of a calcification front across the cartilage. Synovial crystal phagocytosis was also observed. The progressive ankylosis mouse should be an important model for studying both crystal deposition and abnormal articular cartilage calcification.
在4周、6周和8周龄时，使用电子显微镜和电子探针微分析技术对进行性关节强硬小鼠的掌指关节进行了检查。这些研究描述了该疾病的进展情况，并揭示了三个重叠阶段：血管翳增殖、软骨细胞形成与矿化以及关节软骨矿化。软骨细胞的矿化方式与软骨内成骨相当相似，而关节软骨则通过钙化前沿在软骨上的推进而矿化。还观察到滑膜晶体吞噬现象。进行性关节强硬小鼠应该是研究晶体沉积和关节软骨异常钙化的重要模型。
