Sun Shumei S, Sima Adam P, Himes John H
Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, Va., USA.
Ann Nutr Metab. 2014;65(2-3):175-83. doi: 10.1159/000365872. Epub 2014 Nov 18.
Using serial data from the Fels Longitudinal Study, we investigated the effects of early and late attainment of the peak height velocity (PHV) in childhood on the timing of the appearance of the metabolic syndrome later in life. We aimed to show if early attainment of PHV engenders greater risks for chronic diseases in boys than in girls. Therefore, we defined those boys and girls in sex-specific quartiles of the study population that were slowest to attain PHV as having a slow tempo of development, and those in the growth that most rapidly attained PHV as having a rapid tempo of development. Boys who experienced an early onset of PHV tended to have a higher risk for the metabolic syndrome, dyslipidemia and impaired fasting glucose than those who had late onset of PHV. Girls who had an early onset of PHV tended to develop more abdominal obesity than females who had a late onset of PHV.
利用费尔斯纵向研究的系列数据，我们调查了儿童期高峰身高速度（PHV）提前和延迟出现对后期生活中代谢综合征出现时间的影响。我们旨在表明，PHV提前出现是否会使男孩比女孩面临更大的慢性病风险。因此，我们将研究人群中按性别划分的四分位数中达到PHV最慢的男孩和女孩定义为发育节奏缓慢，而将在生长过程中最快达到PHV的男孩和女孩定义为发育节奏快。与PHV出现较晚的男孩相比，PHV出现较早的男孩患代谢综合征、血脂异常和空腹血糖受损的风险往往更高。与PHV出现较晚的女性相比，PHV出现较早的女孩往往更容易出现腹部肥胖。
