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[甲状腺功能减退大鼠体内腺苷代谢酶活性对生长激素水平的依赖性]

[Dependence of the activity of enzymes of adenosine metabolism in hypothyroid rats on the level of somatotropin in the body].

作者信息

Litvinenko E A

出版信息

Probl Endokrinol (Mosk). 1989 Jan-Feb;35(1):76-9.

PMID:2541427
Abstract

Adenosine metabolism in hypothyrosis has been shown to decrease in thymocytes (5'-nucleotidase activity decreases by 18% and adenosine deaminase activity increases in thymocyte light fractions). Activation of adenosine synthesis and decay processes (5'-nucleotidase and adenosine deaminase activity increase by 65 and 72%, respectively) was found in the spleen of hypothyroid rats. Adenosine metabolism returns to normal in the spleen and thymocytes as a result of somatotropin action. Adenosine metabolism in the liver of hypothyroid rats remains unchanged.

摘要

甲状腺功能减退症中,胸腺细胞的腺苷代谢已被证明会降低(5'-核苷酸酶活性降低18%,胸腺细胞轻组分中的腺苷脱氨酶活性增加)。在甲状腺功能减退大鼠的脾脏中发现腺苷合成和降解过程被激活(5'-核苷酸酶和腺苷脱氨酶活性分别增加65%和72%)。由于生长激素的作用,脾脏和胸腺细胞中的腺苷代谢恢复正常。甲状腺功能减退大鼠肝脏中的腺苷代谢保持不变。

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