Umanskiĭ V Iu, Shmal'ko Iu P
Ukr Biokhim Zh (1978). 1986 Mar-Apr;58(2):45-50.
A correlation between reactions of the sympathoadrenal system and the activity of adenosine transformation enzymes in lymphocytes is demonstrated in the dynamics of metastatic Lewis carcinoma development in C57Bl mice. In the period when metastases arise a decrease in the adenosine deaminase activity in lymphoid cells of the thymus and spleen is accompanied by drop in the content of DOPA, noradrenalin and adrenalin in adrenals. At the late stages of the tumour process a decrease in the amount of these compounds in adrenals is accompanied by the diminution of the adenosine deaminase activity and by an increase in the 5'-nucleotidase activity in the thymus. Contrary changes are observed in spleen lymphocytes. The revealed disturbances may stimulate to a considerable extent the appearance and growth of metastases.
在C57Bl小鼠转移性Lewis癌发展的动态过程中，证实了交感肾上腺系统反应与淋巴细胞中腺苷转化酶活性之间的相关性。在转移发生的时期，胸腺和脾脏淋巴样细胞中腺苷脱氨酶活性降低，同时肾上腺中多巴、去甲肾上腺素和肾上腺素的含量下降。在肿瘤进程的后期，肾上腺中这些化合物含量的减少伴随着腺苷脱氨酶活性的降低以及胸腺中5'-核苷酸酶活性的增加。在脾脏淋巴细胞中观察到相反的变化。所揭示的紊乱在很大程度上可能会刺激转移灶的出现和生长。
