中间部分：甲型流感病毒核糖核蛋白。
At the centre: influenza A virus ribonucleoproteins.
作者信息
Eisfeld Amie J, Neumann Gabriele, Kawaoka Yoshihiro
机构信息
School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA.
1] School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA. [2] Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. [3] ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan. [4] Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
出版信息
Nat Rev Microbiol. 2015 Jan;13(1):28-41. doi: 10.1038/nrmicro3367. Epub 2014 Nov 24.
Influenza A viral ribonucleoprotein (vRNP) complexes comprise the eight genomic negative-sense RNAs, each of which is bound to multiple copies of the vRNP and a trimeric viral polymerase complex. The influenza virus life cycle centres on the vRNPs, which in turn rely on host cellular processes to carry out functions that are necessary for the successful completion of the virus life cycle. In this Review, we discuss our current knowledge about vRNP trafficking within host cells and the function of these complexes in the context of the virus life cycle, highlighting how structure contributes to function and the crucial interactions with host cell pathways, as well as on the information gaps that remain. An improved understanding of how vRNPs use host cell pathways is essential to identify mechanisms of virus pathogenicity, host adaptation and, ultimately, new targets for antiviral intervention.
甲型流感病毒核糖核蛋白（vRNP）复合物由八个基因组负链RNA组成，每个RNA都与多个vRNP拷贝和一个三聚体病毒聚合酶复合物结合。流感病毒的生命周期以vRNP为中心，而vRNP又依赖宿主细胞过程来执行病毒生命周期成功完成所必需的功能。在本综述中，我们讨论了我们目前对vRNP在宿主细胞内运输的了解以及这些复合物在病毒生命周期背景下的功能，强调了结构如何促进功能以及与宿主细胞途径的关键相互作用，以及仍然存在的信息空白。更好地理解vRNP如何利用宿主细胞途径对于确定病毒致病性、宿主适应性机制以及最终确定抗病毒干预的新靶点至关重要。
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