简短通讯：HIV RNA水平可预测HIV感染成人开始抗逆转录病毒治疗后出现的艾滋病定义性癌症和非艾滋病定义性癌症。
Short Communication: HIV RNA Levels Predict AIDS-Defining and Non-AIDS-Defining Cancers After Antiretroviral Therapy Initiation Among HIV-Infected Adults.
作者信息
Crum-Cianflone Nancy F, Wang Xun, Ganesan Anuradha, Okulicz Jason, Weintrob Amy, Lalani Tahaniyat, Agan Brian
机构信息
1 Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences , Bethesda, Maryland.
出版信息
AIDS Res Hum Retroviruses. 2015 May;31(5):514-8. doi: 10.1089/AID.2014.0279. Epub 2014 Dec 17.
Abstract
Whether poor virologic control is associated with incident cancers after initiation of combination antiretroviral therapy (ART) remains unclear. In a large cohort, time-updated HIV RNA levels ≥1,000 copies/ml predicted AIDS-defining cancers (ADCs), non-AIDS-defining cancers (NADCs), and skin cancers. Virologic control may be an important strategy in reducing cancer events among HIV-infected persons.
摘要
在开始联合抗逆转录病毒治疗（ART）后，病毒学控制不佳是否与新发癌症相关尚不清楚。在一个大型队列中，随时间更新的HIV RNA水平≥1000拷贝/毫升可预测获得性免疫缺陷综合征定义的癌症（ADC）、非获得性免疫缺陷综合征定义的癌症（NADC）和皮肤癌。病毒学控制可能是减少HIV感染者癌症事件的一项重要策略。
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