通过识别血清淀粉样蛋白β42肽的ADP3类肽进行阿尔茨海默病的无标记检测。
Label-free detection of Alzheimer's disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide.
作者信息
Zhao Zijian, Zhu Ling, Bu Xiangli, Ma Huailei, Yang Shu, Yang Yanlian, Hu Zhiyuan
机构信息
National Center for Nanoscience and Technology, No. 11, Beiyitiao Zhongguancun, Beijing, 100190, P.R. China.
出版信息
Chem Commun (Camb). 2015 Jan 14;51(4):718-21. doi: 10.1039/c4cc07037b.
PMID:25418132
Abstract
The early diagnosis of Alzheimer's disease (AD) is challenging due to the lack of reliable methods for detecting its biomarkers in the noninvasive biopsies. We used surface plasmon resonance imaging to identify AD based on the detection of amyloid-beta42 in the serum by the ADP3 peptoid.
摘要
由于缺乏在非侵入性活检中检测阿尔茨海默病（AD）生物标志物的可靠方法，其早期诊断具有挑战性。我们使用表面等离子体共振成像，通过ADP3类肽检测血清中的β淀粉样蛋白42来识别AD。
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