Henan Key Laboratory Cultivation Base of Nanobiological Analytical Chemistry, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
Small. 2015 May 13;11(18):2144-9. doi: 10.1002/smll.201402593. Epub 2015 Jan 10.
A simple method for specific colorimetric sensing of Alzheimer's disease related amyloid-β peptide (Aβ) is developed based on the aggregation of gold nanoparticles in the presence of copper ion. The detection of limit for Aβ(1-40) is 0.6 nM and the promising results from practical samples (human serum) indicate the great potential for the routine detection.
基于金纳米粒子在铜离子存在下的聚集,开发了一种用于阿尔茨海默病相关淀粉样β肽(Aβ)的特异性比色传感的简单方法。Aβ(1-40)的检测限为 0.6 nM,来自实际样品(人血清)的有希望的结果表明其具有常规检测的巨大潜力。