基于铜离子存在下金纳米粒子聚集的淀粉样β肽(1-40)的简单比色检测。
Simple Colorimetric Detection of Amyloid β-peptide (1-40) based on Aggregation of Gold Nanoparticles in the Presence of Copper Ions.
机构信息
Henan Key Laboratory Cultivation Base of Nanobiological Analytical Chemistry, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
出版信息
Small. 2015 May 13;11(18):2144-9. doi: 10.1002/smll.201402593. Epub 2015 Jan 10.
PMID:25641831
Abstract
A simple method for specific colorimetric sensing of Alzheimer's disease related amyloid-β peptide (Aβ) is developed based on the aggregation of gold nanoparticles in the presence of copper ion. The detection of limit for Aβ(1-40) is 0.6 nM and the promising results from practical samples (human serum) indicate the great potential for the routine detection.
摘要
基于金纳米粒子在铜离子存在下的聚集，开发了一种用于阿尔茨海默病相关淀粉样β肽（Aβ）的特异性比色传感的简单方法。Aβ（1-40）的检测限为 0.6 nM，来自实际样品（人血清）的有希望的结果表明其具有常规检测的巨大潜力。
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