Tahayori Bahman, Meffin Hamish, Sergeev Evgeni N, Mareels Iven M Y, Burkitt Anthony N, Grayden David B
NeuroEngineering Laboratory, Department of Electrical and Electronic Engineering, The University of Melbourne, VIC 3010, Australia.
J Neural Eng. 2014 Dec;11(6):065005. doi: 10.1088/1741-2560/11/6/065005. Epub 2014 Nov 24.
The objective of this paper is to present a concrete application of the cellular composite model for calculating the membrane potential, described in an accompanying paper.
A composite model that is used to determine the membrane potential for both longitudinal and transverse modes of stimulation is demonstrated.
Two extreme limits of the model, near-field and far-field for an electrode close to or distant from a neuron, respectively, are derived in this paper. Results for typical neural tissue are compared using the composite, near-field and far-field models as well as the standard isotropic volume conductor model. The self-consistency of the composite model, its spatial profile response and the extracellular potential time behaviour are presented. The magnitudes of the longitudinal and transverse components for different values of electrode-neurite separations are compared.
The unique features of the composite model and its simplified versions can be used to accurately estimate the spatio-temporal response of neural tissue to extracellular electrical stimulation.
本文的目的是展示在一篇配套论文中描述的用于计算膜电位的细胞复合模型的具体应用。
展示了一个用于确定纵向和横向刺激模式下膜电位的复合模型。
本文推导了该模型的两个极限情况，分别是靠近或远离神经元的电极的近场和远场。使用复合模型、近场模型、远场模型以及标准各向同性体积导体模型对典型神经组织的结果进行了比较。展示了复合模型的自洽性、其空间分布响应以及细胞外电位的时间行为。比较了不同电极 - 神经突间距值下纵向和横向分量的大小。
复合模型及其简化版本的独特特性可用于准确估计神经组织对细胞外电刺激的时空响应。
