细胞外电刺激建模：第4部分。神经组织细胞组成对其时空滤波特性的影响。

Modelling extracellular electrical stimulation: part 4. Effect of the cellular composition of neural tissue on its spatio-temporal filtering properties.

作者信息

Tahayori Bahman, Meffin Hamish, Sergeev Evgeni N, Mareels Iven M Y, Burkitt Anthony N, Grayden David B

机构信息

NeuroEngineering Laboratory, Department of Electrical and Electronic Engineering, The University of Melbourne, VIC 3010, Australia.

出版信息

J Neural Eng. 2014 Dec;11(6):065005. doi: 10.1088/1741-2560/11/6/065005. Epub 2014 Nov 24.

DOI:10.1088/1741-2560/11/6/065005

PMID:25419652

Abstract

OBJECTIVE

The objective of this paper is to present a concrete application of the cellular composite model for calculating the membrane potential, described in an accompanying paper.

APPROACH

A composite model that is used to determine the membrane potential for both longitudinal and transverse modes of stimulation is demonstrated.

MAIN RESULTS

Two extreme limits of the model, near-field and far-field for an electrode close to or distant from a neuron, respectively, are derived in this paper. Results for typical neural tissue are compared using the composite, near-field and far-field models as well as the standard isotropic volume conductor model. The self-consistency of the composite model, its spatial profile response and the extracellular potential time behaviour are presented. The magnitudes of the longitudinal and transverse components for different values of electrode-neurite separations are compared.

SIGNIFICANCE

The unique features of the composite model and its simplified versions can be used to accurately estimate the spatio-temporal response of neural tissue to extracellular electrical stimulation.

摘要