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Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension.

作者信息

Cugini P, Lucia P, Letizia C, Murano G, Scavo D, Giganti G, Calogero A, Verna R

机构信息

I Patologia Medica, Università di Roma La Sapienza, Italia.

出版信息

Enzyme. 1989;41(3):159-67. doi: 10.1159/000469071.

DOI:10.1159/000469071
PMID:2542013
Abstract

The Na,K-ATPase activity of erythrocyte membranes is markedly increased in normal-renin essential hypertensives. A temporal shift of the chronobiology of the erythrocyte-membrane-bound Na,K-ATPase in these patients is described. The disorder causes a loss of synchronism between the circadian rhythms of aldosterone and Na,K-ATPase. Such uncoupling phenomenon may explain the inversion of the day/night sodium excretion ratio and other disturbances of sodium metabolism found in essential hypertensives.

摘要

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