Mazzanti L, Rabini R A, Testa I, Coppa G V, Catassi C, Cecconi M, Giorgi P L
Institute of Biochemistry, University of Ancona, Italy.
Biochem Med Metab Biol. 1991 Apr;45(2):181-7. doi: 10.1016/0885-4505(91)90019-h.
Intracellular sodium concentration and Na+/K(+)-ATPase activity were studied in erythrocytes obtained from members of 14 families with one hypertensive parent and from age-matched control subjects, as part of a study on the genetic and environmental determinants of essential hypertension. We found reduced Na+/K(+)-ATPase activity, increased intracellular Na+ concentration, and reduced urinary Na+ excretion in hypertensive patients as compared with the control subjects. In the offspring of hypertensive parents an increase in intracellular Na+ concentration and a decrease in Na+/K(+)-ATPase activity were observed, with a significant correlation relating such parameters. Normotensive spouses did not differ from the normotensive control adults in any of the parameters studied, suggesting no influence of shared family environment in our family group. These data suggest that there is a strong genetic influence contributing to familiar alterations in cation transport, although long-term studies are needed to evaluate the influence of environmental determinants.
作为一项关于原发性高血压的遗传和环境决定因素研究的一部分，我们对来自14个家庭（每个家庭有一位高血压患者）的成员以及年龄匹配的对照受试者的红细胞中的细胞内钠浓度和钠钾ATP酶活性进行了研究。我们发现，与对照受试者相比，高血压患者的钠钾ATP酶活性降低、细胞内钠浓度升高、尿钠排泄减少。在高血压患者的后代中，观察到细胞内钠浓度升高和钠钾ATP酶活性降低，且这些参数之间存在显著相关性。血压正常的配偶在任何研究参数上与血压正常的对照成年人没有差异，这表明在我们的家庭组中共享的家庭环境没有影响。这些数据表明，尽管需要长期研究来评估环境决定因素的影响，但遗传因素对阳离子转运的家族性改变有很强的影响。
